HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17314511
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 342
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (62-339): 9.49e-75: 238: 16.72
+	Hs
		348035 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NLE1_HUMAN (114-333): 2.06e-53: 184: 18.05
+	Hs
		346090 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		COPB2_HUMAN (54-331): 3.17e-47: 172: 18.38
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (3-236): 1.85e-43: 160: 14.29
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		196936 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (3-236): 1.85e-43: 160: 14.29
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (3-236): 1.85e-43: 160: 14.29
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		898168 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		903353 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Mm
		659344 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		WDR5_MOUSE (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		898091 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79