Protein: SYLC
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)

Gene: SYLC, CDC60
Organism: Saccharomyces cerevisiae S288C
Interactions: 92
UniProt ID: P26637

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006429 - leucyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343806

SYMC
Methionine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

643672

DHH1
ATP-dependent RNA helicase DHH1

2

1

High-throughput

0.601

High

643678

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

3

High-throughput

0.585

High

341649

ARGI
Arginase

2

0

High-throughput

0.576

High

643651

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

643689

RAGAB
GTP-binding protein GTR1

1

2

Small-scale

0.552

High

643690

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

643701

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

High-throughput

0.515

High

643653

ATC5
Phospholipid-transporting ATPase DNF1

1

0

High-throughput

0.493

High

643661

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.493

High

429648

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

5

High-throughput

0.489

High

643657

SUI1
Eukaryotic translation initiation factor eIF-1

1

2

High-throughput

0.489

High

643699

UTP4
U3 small nucleolar RNA-associated protein 4

1

5

High-throughput

0.489

High

643694

STE20
Serine/threonine-protein kinase STE20

1

4

Small-scale

0.481

High

643707

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.481

High

365892

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.479

High

388948

SYTC
Threonine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

389056

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

406835

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

410319

SC160
Protein SCP160

1

1

High-throughput

0.479

High

524190

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

526324

SYQ
Glutamine--tRNA ligase

1

6

High-throughput

0.479

High

543301

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.479

High

546147

SYKC
Lysine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

643650

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

643656

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

643658

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

643659

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

643660

EF1G2
Elongation factor 1-gamma 2

1

3

High-throughput

0.479

High

643662

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

643664

SYG
Glycine--tRNA ligase 1, mitochondrial

1

13

High-throughput

0.479

High

643666

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

643667

YHI0
Putative proline--tRNA ligase YHR020W

1

11

High-throughput

0.479

High

643668

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

643679

ARC1
tRNA-aminoacylation cofactor ARC1

1

8

High-throughput

0.479

High

643684

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

643687

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

643691

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

643692

ESP1
Separin

1

2

High-throughput

0.479

High

643693

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

643696

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

643700

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

643704

ATPD
ATP synthase subunit delta, mitochondrial

1

1

High-throughput

0.470

High

425067

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

615234

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

629235

RBSK
Ribokinase

1

0

High-throughput

0.458

High

643681

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

643685

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.458

High

643686

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.458

High

367796

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

410930

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.445

High

424373

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.445

High

454564

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.445

High

490501

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

493338

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

510455

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

555855

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

643669

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

643675

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

643677

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

643682

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

405469

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

413343

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

627747

SIS1
Protein SIS1

1

5

High-throughput

0.437

High

643649

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

643655

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

643663

HMT1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.437

High

643665

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

643670

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.437

High

643671

SEC31
Protein transport protein SEC31

1

9

High-throughput

0.437

High

643673

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

643698

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

643702

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

643703

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.437

High

333708

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

376660

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

421585

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

635956

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

628840

SWI4
Regulatory protein SWI4

1

0

High-throughput

0.269

Low

643674

DHE5
NADP-specific glutamate dehydrogenase 2

1

0

High-throughput

0.269

Low

357919

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

472051

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

643652

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

High-throughput

0.249

Low

643654

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

643676

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.249

Low

643680

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

643683

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.249

Low

643688

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

643695

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

643697

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.249

Low

643705

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

643706

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024