HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	29467282, 36424410, 21150319
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 2514
+	Hs
		261367 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		348196 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		348119 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RCOR3_HUMAN (351-810): 1.25e-41: 163: 20.65
+	Hs
		348258 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		346565 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MUC3A_HUMAN (1466-2499): 3.05e-21: 104: 7.94
+	Hs
		347668 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		348352 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRC2C_HUMAN (1-1819): 3.07e-18: 94.7: 7.02
+	Hs
		346499 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MAP1A_HUMAN (477-2485): 7.65e-16: 87.1: 9.73
+	Hs
		347455 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61
+	Hs
		380026 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		380070 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRC2C_HUMAN (1-1819): 3.07e-18: 94.7: 7.02
+	Hs
		1218735 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		898219 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		379663 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61
+	Hs
		1314325 MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72		RCOR3_HUMAN (351-810): 1.25e-41: 163: 20.65
+	Hs
		607835 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		1079724 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		1218707 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33