HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 918
+	Hs
		349939 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		770192 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		349822 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		489965 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		1031987 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66
+	Hs
		349083 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		489934 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		350746 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		1070491 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		349043 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		349775 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		914506 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		350424 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		NEO1_HUMAN (128-882): 5.57e-27: 120: 10.99
+	Hs
		348841 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		NEO1_HUMAN (128-882): 5.57e-27: 120: 10.99
+	Hs
		350221 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SDK2_HUMAN (242-918): 1.61e-20: 100: 10.01
+	Hs
		350296 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SDK1_HUMAN (249-918): 1.67e-14: 80.5: 9.65
+	Mm
		514129 RB11A_MOUSE (4-184): 1.5e-74: 224: 33.88		L1CAM_MOUSE (121-918): 5.47e-22: 104: 10.73
+	Hs
		914108 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		SDK2_HUMAN (242-918): 1.61e-20: 100: 10.01
+	Hs
		350405 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TITIN_HUMAN (16-496): 1.42e-10: 67.7: 8.82
+	Hs
		914253 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		TITIN_HUMAN (16-496): 1.42e-10: 67.7: 8.82