Protein: GSHR
Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)

Gene: GSHR, GSR
Organism: Homo sapiens
Interactions: 78
UniProt ID: P00390

Gene Ontology (top 5):
GO:0004362 - glutathione-disulfide reductase (NADPH) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0006749 - glutathione metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360180

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

240421

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

319269

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

360163

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

360164

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

360165

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

360168

ENOA
Alpha-enolase

1

4

High-throughput

0.479

High

360169

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

360172

CD9
CD9 antigen

1

1

High-throughput

0.479

High

360177

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

360178

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

360179

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

360182

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

360186

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

360187

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.479

High

360189

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

360191

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

360199

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

360208

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

360209

OPTN
Optineurin

1

2

High-throughput

0.479

High

360223

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.479

High

257296

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

271798

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

360162

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

360167

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.458

High

360175

CASP1
Caspase-1

1

0

High-throughput

0.458

High

360183

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

360203

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

360214

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

Small-scale

0.457

High

142264

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

295440

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

High-throughput

0.445

High

360174

GRN
Progranulin

1

1

High-throughput

0.445

High

360181

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.445

High

360184

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.445

High

360193

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

360202

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

360210

SYMM
Methionine--tRNA ligase, mitochondrial

1

5

High-throughput

0.445

High

360211

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.445

High

360221

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

360225

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

105049

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

360170

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

360173

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

360176

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

360196

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

360198

ASXL2
Putative Polycomb group protein ASXL2

1

4

High-throughput

0.437

High

360200

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

360201

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.437

High

360216

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

360217

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

360224

DJB11
DnaJ homolog subfamily B member 11

1

2

High-throughput

0.437

High

183568

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.426

High

360188

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

360212

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.426

High

360220

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

360228

TX264
Testis-expressed protein 264

1

0

High-throughput

0.426

High

360166

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

360192

TPD53
Tumor protein D53

1

2

High-throughput

0.407

High

360205

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.407

High

360215

PCGF6
Polycomb group RING finger protein 6

1

1

High-throughput

0.407

High

360204

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

High-throughput

0.282

High

360218

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.282

High

360213

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

217678

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

276743

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.249

Low

360190

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

360194

DUS29
Dual specificity phosphatase 29

1

0

High-throughput

0.249

Low

360195

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

360197

SPERI
Speriolin

1

0

High-throughput

0.249

Low

360207

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

360222

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

360226

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

330013

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

360171

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

360185

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.232

Low

360206

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

360219

ZN331
Zinc finger protein 331

1

0

High-throughput

0.232

Low

360227

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025