HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30442766, 30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras, Ank_4~Ras
Common GO terms	GO:0000139 - Golgi membrane GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 2555
+	Hs
		349957 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		804251 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		349180 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		804192 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		804188 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		NOTC1_HUMAN (20-2555): 0: 1387: 100.00
+	Hs
		350083 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67
+	Hs
		350123 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60
+	Hs
		1021405 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60
+	Hs
		349253 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67
+	Hs
		350675 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ANR50_HUMAN (1862-2553): 1.06e-91: 332: 15.85
+	Hs
		349001 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ANR50_HUMAN (1862-2553): 1.06e-91: 332: 15.85
+	Hs
		350697 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92
+	Hs
		1070463 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92
+	Hs
		350066 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		JAG1_HUMAN (8-429): 2.99e-40: 166: 25.26
+	Hs
		349241 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		JAG1_HUMAN (8-429): 2.99e-40: 166: 25.26
+	Hs
		350099 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		980377 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		348629 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		914022 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77
+	Hs
		895050 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77