HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: S12A2 (P55011)
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2)
Gene: SLC12A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30442766, 30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1212
+	Hs
		350004 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		S12A2_HUMAN (1-1212): 0: 1285: 100.00
+	Hs
		873920 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		S12A2_HUMAN (1-1212): 0: 1285: 100.00
+	Hs
		349223 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		S12A2_HUMAN (1-1212): 0: 1285: 100.00
+	Hs
		873901 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		S12A2_HUMAN (1-1212): 0: 1285: 100.00
+	Hs
		873897 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		S12A2_HUMAN (1-1212): 0: 1285: 100.00
+	Hs
		350657 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		S12A6_HUMAN (148-1212): 0: 918: 22.65
+	Hs
		350688 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		S12A4_HUMAN (167-1212): 0: 914: 23.71
+	Hs
		1070458 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		S12A4_HUMAN (167-1212): 0: 914: 23.71
+	Hs
		349008 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		S12A4_HUMAN (167-1212): 0: 914: 23.71
+	Hs
		349734 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		S12A4_HUMAN (167-1212): 0: 914: 23.71
+	Hs
		895310 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		S12A6_HUMAN (148-1212): 0: 918: 22.65
+	Hs
		914461 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		S12A4_HUMAN (167-1212): 0: 914: 23.71
+	Hs
		350738 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		S12A7_HUMAN (163-1212): 0: 874: 22.62
+	Hs
		1070484 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		S12A7_HUMAN (163-1212): 0: 874: 22.62
+	Hs
		349035 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		S12A7_HUMAN (163-1212): 0: 874: 22.62
+	Hs
		349769 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		S12A7_HUMAN (163-1212): 0: 874: 22.62
+	Hs
		914495 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		S12A7_HUMAN (163-1212): 0: 874: 22.62
+	Mm
		1265035 RAB1B_MOUSE (4-187): 2e-75: 226: 32.47		S12A5_MOUSE (188-1212): 0: 851: 22.08
+	Hs
		350407 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		YLAT2_HUMAN (248-776): 1.22e-113: 366: 11.49
+	Hs
		895209 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		YLAT2_HUMAN (248-776): 1.22e-113: 366: 11.49