HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1591
+	Hs
		350128 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		1022394 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		349282 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		895058 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		279827 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		279866 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		279852 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		350280 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		349105 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		VAV_HUMAN (954-1525): 4.75e-87: 306: 15.72
+	Hs
		350195 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		1070208 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		349422 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		349341 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		914091 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Dm
		1229130 Q962I2_DROME (4-170): 1.83e-59: 186: 51.79		Q8MSP7_DROME (1041-1240): 5.83e-14: 79.7: 29.50
+	Dm
		71594 RALA_DROME (4-169): 1.5e-59: 186: 52.70		B3DN64_DROME (1041-1240): 5.77e-14: 79.7: 29.50
+	Sc
		350788 RAS2_YEAST (3-179): 5.76e-58: 186: 61.54		CDC24_YEAST (1043-1244): 6.36e-14: 79.3: 29.56
+	Sc
		350758 RAS1_YEAST (3-164): 2.3e-57: 184: 64.42		CDC24_YEAST (1043-1244): 6.36e-14: 79.3: 29.56