Protein: TNR1B
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]

Gene: TNR1B, TNFRSF1B
Organism: Homo sapiens
Interactions: 240
UniProt ID: P20333

Gene Ontology (top 5):
GO:0002718 - regulation of cytokine production involved in immune response
GO:0002724 - regulation of T cell cytokine production
GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0003176 - aortic valve development
GO:0003177 - pulmonary valve development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377960

TNFA
Tumor necrosis factor

16

20

Small-scale

0.986

High

377882

TNFB
Lymphotoxin-alpha

3

20

Small-scale

0.858

High

630204

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

16

Small-scale

0.806

High

630262

TRAF2
TNF receptor-associated factor 2

15

20

Small-scale

0.761

High

622515

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

17

Small-scale

0.754

High

630264

TRAF1
TNF receptor-associated factor 1

8

20

Small-scale

0.751

High

630317

FGRL1
Fibroblast growth factor receptor-like 1

1

6

High-throughput

0.691

High

630270

BIRC2
Baculoviral IAP repeat-containing protein 2

4

12

Small-scale

0.683

High

630265

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.624

High

539289

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

3

0

High-throughput

0.622

High

271889

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.618

High

630339

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

3

High-throughput

0.618

High

630389

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

16

Small-scale

0.618

High

630386

ASB3
Ankyrin repeat and SOCS box protein 3

1

5

Small-scale

0.617

High

630221

KC1A
Casein kinase I isoform alpha

2

8

Small-scale

0.602

High

291053

UTP20
Small subunit processome component 20 homolog

2

2

High-throughput

0.601

High

630323

VANG1
Vang-like protein 1

2

3

High-throughput

0.601

High

630245

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

2

4

Small-scale

0.595

High

630365

XPP3
Xaa-Pro aminopeptidase 3

3

1

High-throughput

0.593

High

630209

GRN
Progranulin

1

2

Small-scale

0.586

High

630281

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

2

9

Small-scale

0.584

High

630334

RNF31
E3 ubiquitin-protein ligase RNF31

2

8

Small-scale

0.571

High

213805

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

5

High-throughput

0.536

High

225773

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.536

High

630212

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

630222

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

630257

UBXN1
UBX domain-containing protein 1

1

8

High-throughput

0.536

High

630261

TROP
Trophinin

1

9

High-throughput

0.536

High

630263

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.536

High

630278

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.536

High

630293

RRP12
RRP12-like protein

1

1

High-throughput

0.536

High

630306

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.536

High

630310

LUZP1
Leucine zipper protein 1

1

7

High-throughput

0.536

High

630313

C2CD5
C2 domain-containing protein 5

1

3

High-throughput

0.536

High

630341

KIF2C
Kinesin-like protein KIF2C

1

7

High-throughput

0.536

High

630366

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

2

High-throughput

0.536

High

630373

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.536

High

630377

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.536

High

630379

VANG2
Vang-like protein 2

1

3

High-throughput

0.536

High

630384

FND3A
Fibronectin type-III domain-containing protein 3A

1

7

High-throughput

0.536

High

630388

S4A7
Sodium bicarbonate cotransporter 3

1

4

High-throughput

0.536

High

630284

PKN1
Serine/threonine-protein kinase N1

1

8

Small-scale

0.528

High

471533

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.518

High

289926

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.513

High

630224

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

630233

DRG2
Developmentally-regulated GTP-binding protein 2

1

0

High-throughput

0.513

High

630247

VIGLN
Vigilin

1

0

High-throughput

0.513

High

630308

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.513

High

630330

NKD2
Protein naked cuticle homolog 2

1

0

High-throughput

0.513

High

630336

PRR11
Proline-rich protein 11

1

0

High-throughput

0.513

High

630344

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

630347

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.513

High

630349

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

630356

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.513

High

630375

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

339133

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

2

Small-scale

0.504

High

323168

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

Small-scale

0.501

High

436792

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.501

High

630324

ZN420
Zinc finger protein 420

1

1

High-throughput

0.494

High

630319

KC1AL
Casein kinase I isoform alpha-like

1

12

Small-scale

0.489

High

294912

POP7
Ribonuclease P protein subunit p20

1

1

High-throughput

0.489

High

338771

CBX6
Chromobox protein homolog 6

1

3

High-throughput

0.489

High

630226

KC1E
Casein kinase I isoform epsilon

1

10

High-throughput

0.489

High

630232

TTC3
E3 ubiquitin-protein ligase TTC3

1

14

High-throughput

0.489

High

630253

SP2
Transcription factor Sp2

1

8

High-throughput

0.489

High

630256

ZNF92
Zinc finger protein 92

1

4

High-throughput

0.489

High

630266

STX5
Syntaxin-5

1

4

High-throughput

0.489

High

630268

ORC1
Origin recognition complex subunit 1

1

6

High-throughput

0.489

High

630274

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.489

High

630275

CBX2
Chromobox protein homolog 2

1

3

High-throughput

0.489

High

630279

OZF
Zinc finger protein OZF

1

4

High-throughput

0.489

High

630280

TTF1
Transcription termination factor 1

1

2

High-throughput

0.489

High

630294

ZMYM1
Zinc finger MYM-type protein 1

1

2

High-throughput

0.489

High

630296

ZN770
Zinc finger protein 770

1

3

High-throughput

0.489

High

630299

NFRKB
Nuclear factor related to kappa-B-binding protein

1

3

High-throughput

0.489

High

630300

FIGL1
Fidgetin-like protein 1

1

6

High-throughput

0.489

High

630301

SAMD1
Sterile alpha motif domain-containing protein 1

1

5

High-throughput

0.489

High

630302

SAS6
Spindle assembly abnormal protein 6 homolog

1

10

High-throughput

0.489

High

630303

AEBP2
Zinc finger protein AEBP2

1

8

High-throughput

0.489

High

630311

CEP57
Centrosomal protein of 57 kDa

1

1

High-throughput

0.489

High

630312

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

4

High-throughput

0.489

High

630315

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.489

High

630316

ZN101
Zinc finger protein 101

1

8

High-throughput

0.489

High

630321

Z280C
Zinc finger protein 280C

1

8

High-throughput

0.489

High

630322

CC112
Coiled-coil domain-containing protein 112

1

2

High-throughput

0.489

High

630337

LLR1
Leucine-rich repeat protein 1

1

1

High-throughput

0.489

High

630338

ZN512
Zinc finger protein 512

1

5

High-throughput

0.489

High

630342

CDC6
Cell division control protein 6 homolog

1

7

High-throughput

0.489

High

630346

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

630355

SP130
Histone deacetylase complex subunit SAP130

1

3

High-throughput

0.489

High

630358

SLK
STE20-like serine/threonine-protein kinase

1

2

High-throughput

0.489

High

630359

ZN696
Zinc finger protein 696

1

7

High-throughput

0.489

High

630361

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.489

High

630367

SPS2L
SPATS2-like protein

1

4

High-throughput

0.489

High

630370

FAIM1
Fas apoptotic inhibitory molecule 1

1

1

High-throughput

0.489

High

630387

TNPO3
Transportin-3

1

20

High-throughput

0.489

High

630382

UBQL1
Ubiquilin-1

1

9

High-throughput

0.481

High

2075

A0A0B4J269
Melanocyte-stimulating hormone receptor

1

15

High-throughput

0.479

High

162158

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.479

High

172467

XPO1
Exportin-1

1

17

High-throughput

0.479

High

173856

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

11

High-throughput

0.479

High

177792

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

18

Small-scale

0.479

High

334681

IPO7
Importin-7

1

14

High-throughput

0.479

High

346847

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.479

High

408668

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

420352

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

11

High-throughput

0.479

High

424767

ADT2
ADP/ATP translocase 2

1

5

High-throughput

0.479

High

437091

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.479

High

457226

TBB5
Tubulin beta chain

1

15

High-throughput

0.479

High

462240

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.479

High

474472

VIME
Vimentin

1

4

High-throughput

0.479

High

507074

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

11

High-throughput

0.479

High

534621

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.479

High

536481

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

551949

ADT1
ADP/ATP translocase 1

1

5

High-throughput

0.479

High

552123

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.479

High

590793

TIMP2
Metalloproteinase inhibitor 2

1

4

High-throughput

0.479

High

598004

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

11

High-throughput

0.479

High

600731

HSP76
Heat shock 70 kDa protein 6

1

7

High-throughput

0.479

High

610527

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

630205

FLNA
Filamin-A

1

2

High-throughput

0.479

High

630206

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

630207

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

630208

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.479

High

630210

SPB3
Serpin B3

1

1

High-throughput

0.479

High

630211

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.479

High

630213

HS71L
Heat shock 70 kDa protein 1-like

1

7

High-throughput

0.479

High

630214

MYH9
Myosin-9

1

4

High-throughput

0.479

High

630216

HSPA9
Stress-70 protein, mitochondrial

1

16

High-throughput

0.479

High

630217

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

630218

BCL6
B-cell lymphoma 6 protein

1

7

Small-scale

0.479

High

630220

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.479

High

630223

EFTU
Elongation factor Tu, mitochondrial

1

7

High-throughput

0.479

High

630229

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

13

Small-scale

0.479

High

630231

COPB
Coatomer subunit beta

1

1

High-throughput

0.479

High

630234

XPO2
Exportin-2

1

15

High-throughput

0.479

High

630235

EPIPL
Epiplakin

1

3

High-throughput

0.479

High

630237

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.479

High

630238

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.479

High

630241

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

630243

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.479

High

630244

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

High-throughput

0.479

High

630246

S25A3
Solute carrier family 25 member 3

1

7

High-throughput

0.479

High

630250

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.479

High

630251

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.479

High

630252

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

High-throughput

0.479

High

630254

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

8

High-throughput

0.479

High

630255

CAV1
Caveolin-1

1

5

Small-scale

0.479

High

630259

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

630269

BIRC3
Baculoviral IAP repeat-containing protein 3

1

11

Small-scale

0.479

High

630271

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

18

Small-scale

0.479

High

630276

IMB1
Importin subunit beta-1

1

9

High-throughput

0.479

High

630283

AAAT
Neutral amino acid transporter B(0)

1

3

High-throughput

0.479

High

630328

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

7

High-throughput

0.479

High

630329

GCN1
Stalled ribosome sensor GCN1

1

11

High-throughput

0.479

High

630343

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

Small-scale

0.479

High

630353

ACTBM
Putative beta-actin-like protein 3

1

3

High-throughput

0.479

High

630362

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

9

Small-scale

0.479

High

630368

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.479

High

630381

MYO6
Unconventional myosin-VI

1

7

High-throughput

0.479

High

630385

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

630351

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.470

High

160413

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

573322

ENPL
Endoplasmin

1

0

High-throughput

0.458

High

630239

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

630240

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

630331

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

65332

TCAF2
TRPM8 channel-associated factor 2

1

2

High-throughput

0.445

High

630248

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.445

High

124227

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

189106

IPO8
Importin-8

1

12

High-throughput

0.437

High

220860

XPOT
Exportin-T

1

13

High-throughput

0.437

High

348359

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.437

High

407980

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.437

High

630215

MYH10
Myosin-10

1

4

High-throughput

0.437

High

630219

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.437

High

630228

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.437

High

630230

TXTP
Tricarboxylate transport protein, mitochondrial

1

7

High-throughput

0.437

High

630258

EF1A2
Elongation factor 1-alpha 2

1

4

High-throughput

0.437

High

630273

RCN2
Reticulocalbin-2

1

4

High-throughput

0.437

High

630277

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.437

High

630282

PCH2
Pachytene checkpoint protein 2 homolog

1

5

High-throughput

0.437

High

630285

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.437

High

630289

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.437

High

630304

RS27L
Ribosomal protein eS27-like

1

2

High-throughput

0.437

High

630307

MON2
Protein MON2 homolog

1

8

High-throughput

0.437

High

630314

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.437

High

630333

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

High-throughput

0.437

High

630335

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.437

High

630348

TBB2B
Tubulin beta-2B chain

1

15

High-throughput

0.437

High

630350

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

7

Small-scale

0.437

High

630352

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

5

Small-scale

0.437

High

630357

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

4

High-throughput

0.437

High

630363

XPO5
Exportin-5

1

14

High-throughput

0.437

High

630369

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

High-throughput

0.437

High

630376

HACD3
Very-long-chain

1

1

High-throughput

0.437

High

630383

Q9UQC1
Heat shock protein 72

1

9

High-throughput

0.437

High

630249

CDK17
Cyclin-dependent kinase 17

1

2

High-throughput

0.407

High

630332

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

3

High-throughput

0.407

High

630236

MLF1
Myeloid leukemia factor 1

2

0

High-throughput

0.313

High

251513

CCNT1
Cyclin-T1

1

0

High-throughput

0.279

Low

272880

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.279

Low

324514

HEXI1
Protein HEXIM1

1

0

High-throughput

0.279

Low

542330

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.279

Low

569053

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

607685

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.279

Low

630225

PRI2
DNA primase large subunit

1

0

High-throughput

0.279

Low

630227

DNLI3
DNA ligase 3

1

0

High-throughput

0.279

Low

630260

DYH14
Dynein axonemal heavy chain 14

1

0

High-throughput

0.279

Low

630272

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.279

Low

630286

TPD53
Tumor protein D53

1

0

High-throughput

0.279

Low

630287

GEN
Flap endonuclease GEN homolog 1

1

0

High-throughput

0.279

Low

630288

MOONR
Protein moonraker

1

0

High-throughput

0.279

Low

630290

BOREA
Borealin

1

0

High-throughput

0.279

Low

630291

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

630292

FA76B
Protein FAM76B

1

0

High-throughput

0.279

Low

630297

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.279

Low

630298

ARMX5
Armadillo repeat-containing X-linked protein 5

1

0

High-throughput

0.279

Low

630305

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

630309

CENPV
Centromere protein V

1

0

High-throughput

0.279

Low

630318

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.279

Low

630320

POC5
Centrosomal protein POC5

1

0

High-throughput

0.279

Low

630325

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.279

Low

630326

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.279

Low

630327

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

630340

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.279

Low

630345

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

High-throughput

0.279

Low

630354

IN80B
INO80 complex subunit B

1

0

High-throughput

0.279

Low

630364

AKIP1
A-kinase-interacting protein 1

1

0

High-throughput

0.279

Low

630371

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.279

Low

630372

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.279

Low

630374

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.279

Low

630378

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.279

Low

630380

APC10
Anaphase-promoting complex subunit 10

1

0

High-throughput

0.279

Low

209477

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.249

Low

630242

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.249

Low

630267

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.249

Low

630295

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.249

Low

630360

NOL11
Nucleolar protein 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025