HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HR1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 984
+	Hs
		350201 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PKN2_HUMAN (1-984): 0: 1145: 97.99
+	Hs
		116950 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		SGK1_HUMAN (611-979): 8.56e-147: 444: 38.67
+	Hs
		349992 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16
+	Hs
		350188 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		348674 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		349336 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		349916 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84
+	Hs
		682177 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84
+	Mm
		554949 Q9R0B8_MOUSE (38-188): 2.26e-87: 254: 81.46		KPCE_MOUSE (397-485): 2.05e-14: 79.7: 14.61
+	Hs
		348536 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Hs
		682159 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84
+	Hs
		895051 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37