HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 9154803, 30639242, 30194290, 7706312, 28514442, 27034005, 22605333, 28205554, 33961781, 36585710, 26165597, 24441586, 8668348, 10545207, 16803888, 34591642
Identification Methods two hybrid, proximity labelling technology, pull down, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, nuclear magnetic resonance, static light scattering, molecular sieving, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Ras, RBD~Ras
Common GO terms GO:0000165 - MAPK cascade
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007265 - Ras protein signal transduction
GO:0009887 - animal organ morphogenesis
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 189
Hs

1 766
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Mm
+ Ce
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024