HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: RASF5 (Q8WWW0)
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
Gene: RASSF5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	9488663, 24722188, 24441586, 18596699
Identification Methods	pull down, two hybrid, nuclear magnetic resonance, anti tag coimmunoprecipitation, two hybrid array, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, RA~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 418
+	Hs
		350400 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Mm
		1125490 RASH_MOUSE (16-189): 5.68e-73: 219: 100.00		RASF5_MOUSE (3-418): 0: 574: 85.10
+	Mm
		1125491 RAP1B_MOUSE (1-165): 2.18e-63: 195: 57.49		RASF5_MOUSE (3-418): 0: 574: 85.10
+	Hs
		897926 RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		919655 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		349676 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		RASF1_HUMAN (87-410): 5.15e-145: 418: 45.10
+	Hs
		349983 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RASF2_HUMAN (223-418): 2.59e-56: 190: 26.96
+	Hs
		349196 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		RASF2_HUMAN (223-418): 2.59e-56: 190: 26.96