HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 21041410
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1088
+	Hs
		348536 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		349916 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		AKT2_HUMAN (532-1043): 1.88e-142: 438: 23.64
+	Hs
		914081 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Mm
		554949 Q9R0B8_MOUSE (38-189): 1.59e-82: 242: 99.34		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Hs
		116950 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		348674 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		348715 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		349992 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		350188 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		350237 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		349030 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Hs
		348647 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		350729 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Hs
		350143 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254428 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		914124 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		254430 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		349292 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254466 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		254429 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90