HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	27684187, 30639242, 30194290, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 543
+	Hs
		349069 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		348473 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		433358 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		349095 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SRC_HUMAN (1-543): 0: 601: 74.22
+	Rn
		589762 RASH_RAT (1-188): 6.53e-87: 255: 86.77		SRC_RAT (1-543): 0: 600: 73.67
+	Hs
		348488 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		349066 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FYN_HUMAN (1-543): 0: 582: 72.16
+	Hs
		349836 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		349070 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		348474 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		433769 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		349172 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96
+	Hs
		349807 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		349264 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		BTK_HUMAN (4-537): 1.03e-165: 487: 31.35
+	Hs
		348630 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		BTK_HUMAN (4-537): 1.03e-165: 487: 31.35
+	Hs
		349949 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96
+	Hs
		349222 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA4_HUMAN (4-542): 2.62e-155: 470: 25.00
+	Hs
		348528 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA3_HUMAN (3-535): 2.01e-156: 473: 25.84
+	Hs
		665398 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA3_HUMAN (3-535): 2.01e-156: 473: 25.84
+	Hs
		349904 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		EPHA3_HUMAN (3-535): 2.01e-156: 473: 25.84