Protein: SEM1
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)

Gene: SEM1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P60896

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000724 - double-strand break repair via homologous recombination
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006406 - mRNA export from nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

198591

PSMD3
26S proteasome non-ATPase regulatory subunit 3

7

2

Small-scale

0.964

High

847785

BRCA2
Breast cancer type 2 susceptibility protein

11

0

Small-scale

0.929

High

121718

PSD11
26S proteasome non-ATPase regulatory subunit 11

6

2

Small-scale

0.928

High

893553

PSMD6
26S proteasome non-ATPase regulatory subunit 6

4

1

Small-scale

0.887

High

893558

PCID2
PCI domain-containing protein 2

7

4

Small-scale

0.862

High

893623

PSD13
26S proteasome non-ATPase regulatory subunit 13

4

0

Small-scale

0.823

High

121978

PSD12
26S proteasome non-ATPase regulatory subunit 12

3

1

Small-scale

0.817

High

231290

GANP
Germinal-center associated nuclear protein

2

2

Small-scale

0.754

High

893591

LENG8
Leukocyte receptor cluster member 8

2

3

Small-scale

0.737

High

730227

PRS7
26S proteasome regulatory subunit 7

4

3

Small-scale

0.683

High

130823

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

1

Small-scale

0.676

High

893529

PRS4
26S proteasome regulatory subunit 4

4

3

Small-scale

0.672

High

893543

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

2

Small-scale

0.672

High

475546

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

1

Small-scale

0.660

High

872244

RD23B
UV excision repair protein RAD23 homolog B

3

5

Small-scale

0.650

High

893554

UBE3C
Ubiquitin-protein ligase E3C

3

3

Small-scale

0.650

High

874057

PSMD4
26S proteasome non-ATPase regulatory subunit 4

4

0

Small-scale

0.643

High

870720

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

0

Small-scale

0.642

High

893593

PSMD1
26S proteasome non-ATPase regulatory subunit 1

3

2

Small-scale

0.640

High

893530

PRS8
26S proteasome regulatory subunit 8

3

4

Small-scale

0.633

High

893632

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

3

0

Small-scale

0.622

High

101801

F8WC89
SAC3 domain containing 1

1

2

Small-scale

0.618

High

872129

RD23A
UV excision repair protein RAD23 homolog A

2

6

Small-scale

0.611

High

893563

ECM29
Proteasome adapter and scaffold protein ECM29

2

1

Small-scale

0.611

High

893541

PSME1
Proteasome activator complex subunit 1

2

2

Small-scale

0.601

High

893616

UBQL2
Ubiquilin-2

2

5

Small-scale

0.601

High

276161

PSD10
26S proteasome non-ATPase regulatory subunit 10

3

0

Small-scale

0.597

High

893550

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

Small-scale

0.586

High

893594

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

Small-scale

0.586

High

893556

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

0

Small-scale

0.585

High

572910

PRS6A
26S proteasome regulatory subunit 6A

2

6

Small-scale

0.584

High

893531

PRS10
26S proteasome regulatory subunit 10B

2

4

Small-scale

0.584

High

893542

RAD51
DNA repair protein RAD51 homolog 1

2

0

Small-scale

0.577

High

893552

PSME4
Proteasome activator complex subunit 4

2

0

Small-scale

0.576

High

893597

PAAF1
Proteasomal ATPase-associated factor 1

2

0

Small-scale

0.576

High

893628

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

0

Small-scale

0.576

High

156265

PSA7
Proteasome subunit alpha type-7

2

3

Small-scale

0.571

High

594496

PSB1
Proteasome subunit beta type-1

2

3

Small-scale

0.571

High

637662

PSA2
Proteasome subunit alpha type-2

2

3

Small-scale

0.571

High

798625

PRS6B
26S proteasome regulatory subunit 6B

2

3

Small-scale

0.571

High

893561

INT11
Integrator complex subunit 11

2

1

Small-scale

0.571

High

893609

INT9
Integrator complex subunit 9

2

1

Small-scale

0.571

High

749299

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.561

High

819786

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

0

Small-scale

0.559

High

849172

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

0

Small-scale

0.559

High

676851

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

Small-scale

0.547

High

893568

INT8
Integrator complex subunit 8

2

0

Small-scale

0.547

High

893590

INT4
Integrator complex subunit 4

2

0

Small-scale

0.547

High

893602

INT2
Integrator complex subunit 2

2

0

Small-scale

0.547

High

893610

INT7
Integrator complex subunit 7

2

0

Small-scale

0.547

High

893612

INT10
Integrator complex subunit 10

2

0

Small-scale

0.547

High

893618

INT6
Integrator complex subunit 6

2

0

Small-scale

0.547

High

304100

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.536

High

509577

UBL4A
Ubiquitin-like protein 4A

1

2

Small-scale

0.536

High

803466

BAG6
Large proline-rich protein BAG6

1

4

Small-scale

0.536

High

820866

PRC2A
Protein PRRC2A

1

1

Small-scale

0.536

High

874751

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.536

High

893527

PSME3
Proteasome activator complex subunit 3

1

2

Small-scale

0.536

High

893539

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.536

High

893545

CUL1
Cullin-1

1

2

Small-scale

0.536

High

893546

CUL2
Cullin-2

1

2

Small-scale

0.536

High

893547

CUL4B
Cullin-4B

1

2

Small-scale

0.536

High

893555

NEDD8
NEDD8

1

1

Small-scale

0.536

High

893560

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.536

High

893578

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

1

Small-scale

0.536

High

893581

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

1

Small-scale

0.536

High

893599

RN126
E3 ubiquitin-protein ligase RNF126

1

1

Small-scale

0.536

High

893606

UBQL4
Ubiquilin-4

1

6

Small-scale

0.536

High

893619

PSME2
Proteasome activator complex subunit 2

1

2

Small-scale

0.536

High

893620

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

Small-scale

0.536

High

893621

UBQL1
Ubiquilin-1

1

5

Small-scale

0.536

High

893630

PRC2C
Protein PRRC2C

1

1

Small-scale

0.536

High

650827

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.527

High

122166

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.513

High

202619

TXNL1
Thioredoxin-like protein 1

1

0

Small-scale

0.513

High

231859

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

Small-scale

0.513

High

296892

LTN1
E3 ubiquitin-protein ligase listerin

1

0

Small-scale

0.513

High

314749

PSMG1
Proteasome assembly chaperone 1

1

0

Small-scale

0.513

High

323671

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.513

High

782205

UBA7
Ubiquitin-like modifier-activating enzyme 7

1

0

Small-scale

0.513

High

891399

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

Small-scale

0.513

High

893528

SUMO2
Small ubiquitin-related modifier 2

1

0

Small-scale

0.513

High

893534

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.513

High

893548

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.513

High

893571

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.513

High

893574

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.513

High

893580

ZFN2B
AN1-type zinc finger protein 2B

1

0

Small-scale

0.513

High

893584

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.513

High

893585

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.513

High

893586

PSMG2
Proteasome assembly chaperone 2

1

0

Small-scale

0.513

High

893596

BAG1
BAG family molecular chaperone regulator 1

1

0

Small-scale

0.513

High

893598

PSMG3
Proteasome assembly chaperone 3

1

0

Small-scale

0.513

High

893622

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.513

High

893624

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.513

High

893626

POMP
Proteasome maturation protein

1

0

Small-scale

0.513

High

893627

FBX7
F-box only protein 7

1

0

Small-scale

0.513

High

893631

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.513

High

336437

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

719432

MERL
Merlin

1

0

High-throughput

0.493

High

726693

FUS
RNA-binding protein FUS

1

0

High-throughput

0.493

High

893536

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

893538

NC2B
Protein Dr1

1

0

High-throughput

0.493

High

893559

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.493

High

893633

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.493

High

893570

UBE3B
Ubiquitin-protein ligase E3B

1

2

Small-scale

0.489

High

893614

RN181
E3 ubiquitin-protein ligase RNF181

1

1

Small-scale

0.489

High

214896

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

893601

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.486

High

795486

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.480

High

656438

PSB4
Proteasome subunit beta type-4

1

5

Small-scale

0.479

High

893526

PSA6
Proteasome subunit alpha type-6

1

3

Small-scale

0.479

High

893535

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

893537

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

Small-scale

0.479

High

893562

DDI2
Protein DDI1 homolog 2

1

6

Small-scale

0.479

High

893608

MDN1
Midasin

1

1

Small-scale

0.479

High

278015

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

Small-scale

0.458

High

324309

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

401735

JUN
Transcription factor Jun

1

0

High-throughput

0.458

High

503790

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

508423

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

531101

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

632673

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.458

High

643984

EF1G
Elongation factor 1-gamma

1

0

Small-scale

0.458

High

764355

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

893544

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

Small-scale

0.458

High

893549

CKAP5
Cytoskeleton-associated protein 5

1

0

Small-scale

0.458

High

893557

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

0

Small-scale

0.458

High

893566

TAF2
Transcription initiation factor TFIID subunit 2

1

0

Small-scale

0.458

High

893567

INT5
Integrator complex subunit 5

1

0

Small-scale

0.458

High

893569

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.458

High

893572

DDX42
ATP-dependent RNA helicase DDX42

1

0

Small-scale

0.458

High

893579

RB15B
Putative RNA-binding protein 15B

1

0

Small-scale

0.458

High

893583

PSMF1
Proteasome inhibitor PI31 subunit

1

0

Small-scale

0.458

High

893592

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

893595

ATX2
Ataxin-2

1

0

Small-scale

0.458

High

893604

RPF2
Ribosome production factor 2 homolog

1

0

Small-scale

0.458

High

893615

CCD39
Coiled-coil domain-containing protein 39

1

0

Small-scale

0.458

High

893617

NARF
Nuclear prelamin A recognition factor

1

0

Small-scale

0.458

High

893625

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.458

High

698

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.445

High

87550

C9JUP7
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

92614

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.445

High

108937

H0YKT8
Proteasome subunit beta

1

4

High-throughput

0.445

High

656188

PSA5
Proteasome subunit alpha type-5

1

3

High-throughput

0.445

High

893540

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

893629

TLN2
Talin-2

1

1

Small-scale

0.437

High

123893

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

181405

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.426

High

583445

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.426

High

624839

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.426

High

864932

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.426

High

893532

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

893533

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.426

High

893551

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.426

High

893575

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.426

High

893576

INT1
Integrator complex subunit 1

1

0

High-throughput

0.426

High

893587

INT12
Integrator complex subunit 12

1

0

High-throughput

0.426

High

893603

NELFA
Negative elongation factor A

1

0

High-throughput

0.426

High

893605

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.426

High

893607

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.426

High

893611

INT13
Integrator complex subunit 13

1

0

High-throughput

0.426

High

893613

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.426

High

147978

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

Small-scale

0.279

Low

893564

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.279

Low

893577

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

Small-scale

0.279

Low

660452

GRN
Progranulin

1

0

High-throughput

0.268

Low

893565

Q6NUL7
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low

893582

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

893573

DNAI3
Dynein axonemal intermediate chain 3

1

0

Small-scale

0.249

Low

893588

RBM33
RNA-binding protein 33

1

0

Small-scale

0.249

Low

893600

DYH6
Dynein axonemal heavy chain 6

1

0

Small-scale

0.249

Low

893589

Q96H21
HCG2012301

1

0

High-throughput

0.238

Low

64296

AN36A
Ankyrin repeat domain-containing protein 36A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024