HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 740
+	Hs
		349336 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		348674 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		350188 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		348536 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		682177 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		349916 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		682159 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		116950 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36