HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 694
+	Hs
		349293 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		348648 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1035374 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		349739 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		349013 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		349619 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DOCK9_HUMAN (3-556): 1.29e-117: 390: 14.81
+	Hs
		1070378 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DOCK9_HUMAN (3-556): 1.29e-117: 390: 14.81
+	Hs
		350515 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DOCK9_HUMAN (3-556): 1.29e-117: 390: 14.81
+	Hs
		350225 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DOC11_HUMAN (3-563): 1.15e-114: 381: 13.19
+	Hs
		1070251 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		349655 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		348930 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		350257 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		1070402 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		350563 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		348931 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		1070403 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		297805 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		K0754_HUMAN (339-656): 1.08e-09: 64.4: 11.22
+	Hs
		297829 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		K0754_HUMAN (339-656): 1.08e-09: 64.4: 11.22
+	Hs
		297806 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		K0754_HUMAN (339-656): 1.08e-09: 64.4: 11.22