Protein: EXOS8
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)

Gene: EXOS8, EXOSC8
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q96B26

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384033

EXOS5
Exosome complex component RRP46

14

19

Small-scale

0.985

High

1384053

EXOS1
Exosome complex component CSL4

9

20

High-throughput

0.974

High

1384034

EXOS3
Exosome complex component RRP40

7

12

Small-scale

0.967

High

1384031

EXOS4
Exosome complex component RRP41

6

19

Small-scale

0.953

High

1353555

DI3L1
DIS3-like exonuclease 1

6

19

Small-scale

0.952

High

1118314

EXOS2
Exosome complex component RRP4

6

20

Small-scale

0.945

High

1054496

EXOS9
Exosome complex component RRP45

5

18

High-throughput

0.927

High

1137652

EXOS7
Exosome complex component RRP42

5

17

High-throughput

0.923

High

1383998

EXOS8
Exosome complex component RRP43

4

16

High-throughput

0.900

High

1209107

EXOS6
Exosome complex component MTR3

3

19

Small-scale

0.828

High

1384052

RRP44
Exosome complex exonuclease RRP44

2

19

Small-scale

0.806

High

1032215

EXOSX
Exosome complex component 10

8

12

Small-scale

0.748

High

1384008

MPH6
M-phase phosphoprotein 6

5

7

Small-scale

0.716

High

1384056

RBM7
RNA-binding protein 7

5

8

High-throughput

0.715

High

1384014

DUS23
Dual specificity protein phosphatase 23

4

2

High-throughput

0.709

High

1384054

HBS1L
HBS1-like protein

4

4

Small-scale

0.696

High

1240249

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

3

High-throughput

0.694

High

574409

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

4

1

High-throughput

0.690

High

480257

RU1C
U1 small nuclear ribonucleoprotein C

4

1

High-throughput

0.686

High

878533

PAXI
Paxillin

5

0

High-throughput

0.682

High

155793

TXND9
Thioredoxin domain-containing protein 9

3

1

High-throughput

0.675

High

1032386

OTUD4
OTU domain-containing protein 4

3

1

High-throughput

0.675

High

1119073

C1D
Nuclear nucleic acid-binding protein C1D

3

3

High-throughput

0.667

High

1032031

TFAP4
Transcription factor AP-4

3

0

High-throughput

0.646

High

1384011

TXD17
Thioredoxin domain-containing protein 17

3

0

High-throughput

0.646

High

1336385

SLAI1
SLAIN motif-containing protein 1

3

0

High-throughput

0.626

High

1336576

MORN4
MORN repeat-containing protein 4

3

0

High-throughput

0.626

High

288485

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

5

High-throughput

0.606

High

350100

SNAI1
Zinc finger protein SNAI1

2

1

High-throughput

0.606

High

1127364

CASL
Enhancer of filamentation 1

2

1

High-throughput

0.606

High

1225035

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

2

High-throughput

0.606

High

1348407

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1384037

FX4L1
Forkhead box protein D4-like 1

2

3

High-throughput

0.606

High

1384055

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

4

High-throughput

0.606

High

508401

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.595

High

1311367

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.589

High

223243

PRC1
Protein regulator of cytokinesis 1

2

1

High-throughput

0.586

High

589358

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.584

High

696155

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

768841

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

838769

MTREX
Exosome RNA helicase MTR4

2

15

High-throughput

0.584

High

1129686

MDC1
Mediator of DNA damage checkpoint protein 1

2

3

High-throughput

0.584

High

762702

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

1

High-throughput

0.584

High

1384016

PDIP3
Polymerase delta-interacting protein 3

2

1

High-throughput

0.584

High

155176

SOCS7
Suppressor of cytokine signaling 7

2

0

High-throughput

0.580

High

297847

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.580

High

325443

RPP14
Ribonuclease P protein subunit p14

2

0

High-throughput

0.580

High

604847

HXB9
Homeobox protein Hox-B9

2

0

High-throughput

0.580

High

829126

RFC5
Replication factor C subunit 5

2

0

High-throughput

0.580

High

933876

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

1081435

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1129215

KCJ11
ATP-sensitive inward rectifier potassium channel 11

2

0

High-throughput

0.580

High

1383999

PF21A
PHD finger protein 21A

2

0

High-throughput

0.580

High

1384001

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1384002

MACIR
Macrophage immunometabolism regulator

2

0

High-throughput

0.580

High

1384003

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1384015

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1384020

SPC1L
Speriolin-like protein

2

0

High-throughput

0.580

High

1384030

MYOZ1
Myozenin-1

2

0

High-throughput

0.580

High

1384051

RASD1
Dexamethasone-induced Ras-related protein 1

2

0

High-throughput

0.580

High

583593

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.573

High

1150148

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.573

High

396672

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

965499

LMO4
LIM domain transcription factor LMO4

2

1

High-throughput

0.553

High

1048955

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

1125825

FRG1
Protein FRG1

1

0

High-throughput

0.549

High

1355866

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.549

High

704546

RXRB
Retinoic acid receptor RXR-beta

1

8

High-throughput

0.541

High

1123214

DPYL1
Dihydropyrimidinase-related protein 1

1

3

High-throughput

0.541

High

447293

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

624111

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

High-throughput

0.536

High

849219

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

859387

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

1051035

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

1384019

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.536

High

1215275

Q5TAL4
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.515

High

1290561

Q86VL0
TCEA2 protein

1

1

High-throughput

0.515

High

837778

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

1350982

BRSK1
Serine/threonine-protein kinase BRSK1

1

0

High-throughput

0.513

High

1384024

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1384032

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1384048

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

133875

FOXN3
Forkhead box protein N3

1

3

High-throughput

0.508

High

178041

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

6

High-throughput

0.508

High

1384021

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.508

High

1384026

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.508

High

1384028

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

2

High-throughput

0.508

High

1384047

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

6

High-throughput

0.508

High

1351414

CABL1
CDK5 and ABL1 enzyme substrate 1

1

0

High-throughput

0.493

High

688294

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.486

High

1384036

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.486

High

1384045

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.486

High

1384057

FHOD1
FH1/FH2 domain-containing protein 1

1

0

High-throughput

0.486

High

284197

SRS10
Serine/arginine-rich splicing factor 10

1

5

High-throughput

0.481

High

288988

ERAL1
GTPase Era, mitochondrial

1

4

High-throughput

0.481

High

321622

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.481

High

428899

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.481

High

478148

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.481

High

655296

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.481

High

991221

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

2

High-throughput

0.481

High

1066431

RBBP4
Histone-binding protein RBBP4

1

5

High-throughput

0.481

High

1111173

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.481

High

1150787

SF01
Splicing factor 1

1

1

High-throughput

0.481

High

1213304

RM02
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.481

High

1316428

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.481

High

1329070

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.481

High

1359873

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

7

High-throughput

0.481

High

1384013

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

3

High-throughput

0.481

High

1384017

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.481

High

1384025

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

2

High-throughput

0.481

High

1384027

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.481

High

1384039

RBM22
Pre-mRNA-splicing factor RBM22

1

3

High-throughput

0.481

High

1384042

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

129315

MEN1
Menin

1

3

High-throughput

0.479

High

252136

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

3

High-throughput

0.479

High

315858

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

319965

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

332110

MRP6
ATP-binding cassette sub-family C member 6

1

2

Small-scale

0.479

High

346170

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

414372

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

854903

RECQ1
ATP-dependent DNA helicase Q1

1

4

High-throughput

0.479

High

905008

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

914959

THOP1
Thimet oligopeptidase

1

3

High-throughput

0.479

High

970890

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

980997

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1017091

H33
Histone H3.3

1

1

High-throughput

0.479

High

1092204

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1100206

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1155640

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1161593

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1251404

GGYF2
GRB10-interacting GYF protein 2

1

3

High-throughput

0.479

High

1254969

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1334738

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1352676

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1364504

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1366975

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1384004

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1384009

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1384022

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1384035

ANLN
Anillin

1

3

High-throughput

0.479

High

1384038

DCA13
DDB1- and CUL4-associated factor 13

1

9

Small-scale

0.479

High

1384041

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.479

High

1384044

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1357109

Q8WUT1
POLDIP3 protein

1

1

High-throughput

0.470

High

1358797

Q8WVZ3
MORN repeat containing 4

1

1

High-throughput

0.470

High

810270

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.460

High

983326

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.460

High

1006610

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.460

High

1013167

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.460

High

1089498

ILF2
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.460

High

1191540

TBRG1
Transforming growth factor beta regulator 1

1

0

High-throughput

0.460

High

1200947

SGO2
Shugoshin 2

1

0

High-throughput

0.460

High

1311589

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.460

High

1336593

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.460

High

1384000

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.460

High

1384007

UIF
UAP56-interacting factor

1

0

High-throughput

0.460

High

1384010

PKP2
Plakophilin-2

1

0

High-throughput

0.460

High

1384023

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.460

High

1384043

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.460

High

1384050

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.460

High

349194

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

799379

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

904057

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1137443

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1384012

MET22
Methyltransferase-like protein 22

1

0

High-throughput

0.458

High

1384040

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1384046

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1112445

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

Small-scale

0.457

High

430214

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1234900

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

1009277

PRR3
Proline-rich protein 3

1

1

High-throughput

0.439

High

1290635

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

1384029

DNJC4
DnaJ homolog subfamily C member 4

1

2

High-throughput

0.437

High

1384049

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

1295079

F90A1
Protein FAM90A1

3

0

High-throughput

0.352

High

1242990

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1337046

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.316

High

1384006

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1384018

HPLN2
Hyaluronan and proteoglycan link protein 2

2

0

High-throughput

0.316

High

634149

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.299

High

1294604

CONA1

1

0

High-throughput

0.299

High

1186

GVQW2
Putative uncharacterized protein CCDC28A-AS1

1

0

High-throughput

0.251

Low

1159951

CCL14
C-C motif chemokine 14

1

0

High-throughput

0.251

Low

1384005

DAA10
Dynein axonemal assembly factor 10

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025