HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: RGPA2 (Q2PPJ7)
Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220)
Gene: RALGAPA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1873
+	Hs
		349358 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RGPA2_HUMAN (1-1873): 0: 2869: 100.00
+	Hs
		914099 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RGPA2_HUMAN (1-1873): 0: 2869: 100.00
+	Hs
		349400 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		1070249 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		350254 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		895128 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		914140 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		914181 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		196392 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SI1L1_HUMAN (1544-1861): 3.5e-92: 335: 19.45
+	Hs
		350638 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SI1L2_HUMAN (1544-1861): 8.65e-90: 327: 20.67
+	Hs
		835037 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		TSC2_HUMAN (1477-1868): 4.37e-100: 360: 23.42
+	Hs
		506370 RALA_HUMAN (4-169): 5.37e-58: 182: 53.29		TSC2_HUMAN (1477-1868): 4.37e-100: 360: 23.42
+	Hs
		812875 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		RPGP1_HUMAN (1554-1848): 7.33e-94: 321: 21.45
+	Hs
		812872 RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49		RPGP1_HUMAN (1554-1848): 7.33e-94: 321: 21.45