HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PLCB1 (Q9NQ66)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
Gene: PLCB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1216
+	Hs
		349665 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		348942 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		1070411 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		895288 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		349256 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCB3_HUMAN (1-1216): 0: 1054: 53.08
+	Hs
		350087 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCB3_HUMAN (1-1216): 0: 1054: 53.08
+	Hs
		914080 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PLCB4_HUMAN (16-1155): 0: 1002: 38.85
+	Hs
		349735 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCL2_HUMAN (18-1017): 0: 844: 26.03
+	Hs
		350690 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCL2_HUMAN (18-1017): 0: 844: 26.03
+	Hs
		349202 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		348580 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		349987 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		349695 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCE1_HUMAN (169-950): 1.87e-172: 565: 22.88
+	Hs
		348976 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCE1_HUMAN (169-950): 1.87e-172: 565: 22.88
+	Hs
		253284 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCH2_HUMAN (464-792): 2.59e-96: 339: 31.58
+	Hs
		348700 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		1070221 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		350215 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		895108 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		580971 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PLCG1_HUMAN (491-792): 9.61e-80: 289: 31.29