HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: KDIS (Q9ULH0)
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Gene: KIDINS220

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras, Ank_4~Ras
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1771
+	Hs
		349000 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		1070450 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		895318 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		914450 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Dm
		1248518 Q962I2_DROME (4-178): 1.03e-60: 189: 51.14		Q8SWY2_DROME (1-465): 9.94e-134: 445: 23.44
+	Hs
		349001 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ANR50_HUMAN (1-307): 2.84e-80: 295: 31.27
+	Hs
		350675 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ANR50_HUMAN (1-307): 2.84e-80: 295: 31.27
+	Hs
		1021405 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		350123 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		349253 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		350083 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Dm
		65552 RALA_DROME (4-182): 3.4e-60: 187: 52.22		A8JNM5_DROME (191-505): 7.26e-65: 247: 18.21
+	Hs
		349212 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DAPK1_HUMAN (4-305): 4.92e-35: 149: 31.58
+	Hs
		862018 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		DAPK1_HUMAN (4-305): 4.92e-35: 149: 31.58
+	Mm
		71299 RAB13_MOUSE (4-188): 2.76e-75: 226: 35.05		ANR44_MOUSE (1-103): 1.84e-18: 94.4: 19.63