HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 857
+	Hs
		349009 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		1070459 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		1066121 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ACAP2_HUMAN (308-854): 7.28e-132: 414: 16.55
+	Mm
		1186345 RAB1B_MOUSE (4-187): 1.74e-73: 221: 31.96		ASAP2_MOUSE (367-855): 3.55e-96: 324: 19.77
+	Hs
		349517 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ASAP3_HUMAN (367-854): 3.9e-84: 290: 18.48
+	Hs
		349535 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		350406 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		349231 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		348601 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Zm
		73944 B4FAE1_MAIZE (4-187): 8.1e-78: 232: 32.82		B4FAE1_MAIZE (68-273): 7.21e-79: 255: 21.13
+	Hs
		918874 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Mm
		918986 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB1A_MOUSE (72-257): 3.27e-72: 237: 24.35
+	Hs
		350037 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		895026 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918846 RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918944 RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Mm
		919000 RAB1B_MOUSE (4-187): 1.74e-73: 221: 31.96		RAB1A_MOUSE (72-257): 3.27e-72: 237: 24.35
+	Hs
		913992 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		896605 RAB14_HUMAN (4-184): 3.77e-72: 218: 29.51		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897876 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75