Protein: IDS
Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]

Gene: IDS
Organism: Homo sapiens
Interactions: 124
UniProt ID: P22304

Gene Ontology (top 5):
GO:0004423 - iduronate-2-sulfatase activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0006027 - glycosaminoglycan catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

647332

GALNS
N-acetylgalactosamine-6-sulfatase

3

7

High-throughput

0.861

High

647335

SPHM
N-sulphoglucosamine sulphohydrolase

1

7

High-throughput

0.691

High

467816

BGLR
Beta-glucuronidase

3

2

High-throughput

0.667

High

647351

CUL1
Cullin-1

3

2

High-throughput

0.667

High

647410

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

3

3

High-throughput

0.667

High

647416

FBX3
F-box only protein 3

3

7

High-throughput

0.667

High

647361

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

3

0

High-throughput

0.638

High

647417

PPT2
Lysosomal thioesterase PPT2

3

0

High-throughput

0.638

High

647383

SUMF1
Formylglycine-generating enzyme

4

13

Small-scale

0.630

High

534630

BIP
Endoplasmic reticulum chaperone BiP

2

7

High-throughput

0.611

High

618176

AMD
Peptidyl-glycine alpha-amidating monooxygenase

2

1

High-throughput

0.611

High

647359

TBB8
Tubulin beta-8 chain

2

2

High-throughput

0.611

High

647421

LOXL2
Lysyl oxidase homolog 2

2

1

High-throughput

0.611

High

215704

COCH
Cochlin

3

1

High-throughput

0.609

High

322579

FBX21
F-box only protein 21

3

6

High-throughput

0.609

High

337249

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

3

3

High-throughput

0.609

High

647354

MESD
LRP chaperone MESD

3

5

High-throughput

0.609

High

647357

TAZ
Tafazzin

3

2

High-throughput

0.609

High

647366

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

3

1

High-throughput

0.609

High

647373

DYR2
Dihydrofolate reductase 2, mitochondrial

3

1

High-throughput

0.609

High

647374

P3H3
Prolyl 3-hydroxylase 3

3

3

High-throughput

0.609

High

647397

KLH15
Kelch-like protein 15

3

1

High-throughput

0.609

High

323024

WDR47
WD repeat-containing protein 47

2

0

High-throughput

0.585

High

647420

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.585

High

647337

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

2

1

High-throughput

0.558

High

647353

PDIA5
Protein disulfide-isomerase A5

2

5

High-throughput

0.558

High

647364

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

1

High-throughput

0.558

High

647370

B3GLT
Beta-1,3-glucosyltransferase

2

1

High-throughput

0.558

High

647389

SC65
Endoplasmic reticulum protein SC65

2

2

High-throughput

0.558

High

136594

MANBA
Beta-mannosidase

1

2

High-throughput

0.536

High

350687

NOE2
Noelin-2

1

1

High-throughput

0.536

High

439638

INSR
Insulin receptor

1

2

High-throughput

0.536

High

573327

ENPL
Endoplasmin

1

6

High-throughput

0.536

High

647327

CALR
Calreticulin

1

9

High-throughput

0.536

High

647341

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.536

High

647343

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

1

High-throughput

0.536

High

647346

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

6

High-throughput

0.536

High

647349

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.536

High

647368

CSPG4
Chondroitin sulfate proteoglycan 4

1

5

High-throughput

0.536

High

647369

CREL2
Protein disulfide isomerase CRELD2

1

5

High-throughput

0.536

High

647372

PODN
Podocan

1

1

High-throughput

0.536

High

647385

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

647400

LGMN
Legumain

1

1

High-throughput

0.536

High

351474

FTCD
Formimidoyltransferase-cyclodeaminase

1

0

High-throughput

0.518

High

647344

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

317235

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.513

High

571226

PERF
Perforin-1

1

0

High-throughput

0.513

High

647333

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

647339

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

647345

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.513

High

647348

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

647393

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

647403

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.513

High

647408

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.513

High

647415

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.513

High

647418

MA2B2
Epididymis-specific alpha-mannosidase

1

0

High-throughput

0.513

High

160807

TOR1B
Torsin-1B

1

1

High-throughput

0.489

High

193675

TPSN
Tapasin

1

3

High-throughput

0.489

High

273748

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

3

High-throughput

0.489

High

291985

CRTAP
Cartilage-associated protein

1

2

High-throughput

0.489

High

380613

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

3

High-throughput

0.489

High

465405

IGF1R
Insulin-like growth factor 1 receptor

1

2

High-throughput

0.489

High

566550

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.489

High

647326

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.489

High

647328

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

4

High-throughput

0.489

High

647329

ERP29
Endoplasmic reticulum resident protein 29

1

5

High-throughput

0.489

High

647330

PDIA3
Protein disulfide-isomerase A3

1

3

High-throughput

0.489

High

647331

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.489

High

647336

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

647340

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.489

High

647350

OS9
Protein OS-9

1

2

High-throughput

0.489

High

647352

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

1

High-throughput

0.489

High

647362

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

1

High-throughput

0.489

High

647367

TXD11
Thioredoxin domain-containing protein 11

1

7

High-throughput

0.489

High

647376

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

High-throughput

0.489

High

647378

VWDE
von Willebrand factor D and EGF domain-containing protein

1

5

High-throughput

0.489

High

647384

TTC13
Tetratricopeptide repeat protein 13

1

4

High-throughput

0.489

High

647388

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.489

High

647392

HMR1
Major histocompatibility complex class I-related protein 1

1

1

High-throughput

0.489

High

647396

NAR5
Ecto-ADP-ribosyltransferase 5

1

2

High-throughput

0.489

High

647402

CNPY3
Protein canopy homolog 3

1

2

High-throughput

0.489

High

647404

CNTP3
Contactin-associated protein-like 3

1

6

High-throughput

0.489

High

647411

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

2

High-throughput

0.489

High

647412

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.489

High

647413

SE1L1
Protein sel-1 homolog 1

1

3

High-throughput

0.489

High

647419

PDIP2
Polymerase delta-interacting protein 2

1

7

High-throughput

0.489

High

464811

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

612868

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

647399

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

647382

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

13

Small-scale

0.457

High

647380

POC5
Centrosomal protein POC5

1

2

Small-scale

0.445

High

370562

FOS
Protein c-Fos

1

2

High-throughput

0.437

High

647338

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.437

High

647381

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

647409

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

647398

CNT3B
Contactin-associated protein-like 3B

1

5

High-throughput

0.407

High

647347

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

3

0

High-throughput

0.347

High

647358

TECT1
Tectonic-1

3

0

High-throughput

0.347

High

647363

GT253
Inactive glycosyltransferase 25 family member 3

3

0

High-throughput

0.347

High

647386

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

3

0

High-throughput

0.347

High

277066

ENTP5
Nucleoside diphosphate phosphatase ENTPD5

2

0

High-throughput

0.318

High

647391

EXT2
Exostosin-2

2

0

High-throughput

0.318

High

647406

XYLT2
Xylosyltransferase 2

2

0

High-throughput

0.318

High

647334

5HT6R
5-hydroxytryptamine receptor 6

1

0

High-throughput

0.282

High

647395

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

135776

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

144229

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.279

Low

212057

B4GT5
Beta-1,4-galactosyltransferase 5

1

0

High-throughput

0.279

Low

647342

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.279

Low

647355

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.279

Low

647356

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

647360

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.279

Low

647365

METRL
Meteorin-like protein

1

0

High-throughput

0.279

Low

647375

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

647377

TRM2A
tRNA

1

0

High-throughput

0.279

Low

647379

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

0

High-throughput

0.279

Low

647387

NLGN2
Neuroligin-2

1

0

High-throughput

0.279

Low

647390

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.279

Low

647394

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

647401

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

647405

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.279

Low

647414

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

647371

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

0

High-throughput

0.249

Low

647407

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025