HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: MRCKB (Q9Y5S2)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Gene: CDC42BPB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1711
+	Hs
		349030 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MRCKB_HUMAN (1-1711): 0: 1556: 100.00
+	Hs
		1070480 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MRCKB_HUMAN (1-1711): 0: 1556: 100.00
+	Hs
		349389 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		348715 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		1070238 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		349329 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		STK38_HUMAN (4-421): 5.25e-119: 385: 38.77
+	Hs
		296393 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		STK10_HUMAN (43-1015): 1.26e-120: 406: 16.50
+	Hs
		349719 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		348995 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		349336 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		348674 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		350188 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		349671 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		254429 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ROCK2_HUMAN (362-1073): 2.09e-23: 110: 13.59
+	Hs
		254428 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ROCK2_HUMAN (362-1073): 2.09e-23: 110: 13.59
+	Hs
		349292 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02
+	Hs
		348647 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02
+	Hs
		254430 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ROCK2_HUMAN (362-1073): 2.09e-23: 110: 13.59
+	Hs
		1035173 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02
+	Hs
		350143 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02