HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: NFAC2 (Q13469)
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
Gene: NFATC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	16027109, 12560487
Identification Methods	DNase I footprinting, electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009410 - response to xenobiotic stimulus GO:0010628 - positive regulation of gene expression GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 925
+	Hs
		352598 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC3_HUMAN (25-921): 0: 707: 32.85
+	Hs
		669883 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		NFAC2_HUMAN (1-925): 0: 860: 100.00
+	Mm
		78126 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		B5B2U4_MOUSE (25-921): 0: 683: 32.92
+	Hs
		317883 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC1_HUMAN (15-923): 0: 630: 41.20
+	Hs
		352617 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAC4_HUMAN (26-919): 0: 574: 33.78
+	Hs
		155683 TNF11_HUMAN (52-233): 5.98e-50: 167: 18.14		NFAC3_HUMAN (25-921): 0: 707: 32.85
+	Hs
		317913 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		NFAC1_HUMAN (15-923): 0: 630: 41.20
+	Hs
		300514 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NFAT5_HUMAN (284-903): 5.37e-126: 417: 25.59
+	Hs
		352589 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TF65_HUMAN (394-918): 3.44e-127: 397: 17.89
+	Mm
		420412 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NFAT5_MOUSE (284-903): 1.54e-126: 419: 25.56
+	Mm
		420397 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		TF65_MOUSE (394-918): 6.13e-126: 393: 17.65
+	Hs
		352584 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		RELB_HUMAN (394-835): 2.85e-103: 335: 16.49
+	Mm
		420392 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NFKB1_MOUSE (382-697): 6.41e-105: 350: 17.86
+	Mm
		420398 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		RELB_MOUSE (393-836): 2.31e-106: 342: 16.28
+	Hs
		669879 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		REL_HUMAN (408-887): 1.1e-124: 392: 15.77