HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	34853447, 21822306
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 604
+	Hs
		352608 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		669884 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		207235 TNF14_HUMAN (75-233): 5.54e-57: 183: 27.44		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		669885 CD40L_HUMAN (48-233): 1.16e-45: 154: 24.49		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		352415 TNFB_HUMAN (58-233): 1.45e-43: 147: 30.06		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		352678 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		MIB2_HUMAN (544-603): 2.9e-10: 65.3: 35.00