Interactor 1: IL2RA (P01589)
Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25)
Gene: IL2RA
Interactor 2: IL2 (P60568)
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Gene: IL2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 35631447, 17032757, 12649439, 8960125, 8894436, 8580082, 1940342, 3095922, 6815536, 15178252 |
| Identification Methods | pull down, solid phase assay, nuclear magnetic resonance, surface plasmon resonance, competition binding, protein cross-linking with a bifunctional reagent, anti tag coimmunoprecipitation, isothermal titration calorimetry |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL2~Sushi |
| Common GO terms | GO:0006955 - immune response GO:0038110 - interleukin-2-mediated signaling pathway GO:0042104 - positive regulation of activated T cell proliferation GO:0046013 - regulation of T cell homeostatic proliferation GO:0050728 - negative regulation of inflammatory response and 2 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
