Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2
Interactor 2: MPIP3 (P30307)
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
Gene: CDC25C
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.983 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28094252, 25361978, 11053450, 16311512, 12897801, 28430840, 16481012, 16540636, 16705183, 12024051, 12402044, 12909615, 11438675, 10744722 |
| Identification Methods | affinity chromatography technology, enzymatic study |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Pkinase~Rhodanese |
| Common GO terms | GO:0000086 - G2/M transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0019901 - protein kinase binding and 1 others more... |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
