Protein: CHK2
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)

Gene: CHK2, CHEK2
Organism: Homo sapiens
Interactions: 212
UniProt ID: O96017

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

354875

CHK2
Serine/threonine-protein kinase Chk2

13

15

Small-scale

0.985

High

354916

MPIP3
M-phase inducer phosphatase 3

14

4

Small-scale

0.983

High

354915

MPIP1
M-phase inducer phosphatase 1

6

4

Small-scale

0.948

High

354930

PLK1
Serine/threonine-protein kinase PLK1

3

18

Small-scale

0.892

High

355033

PLK3
Serine/threonine-protein kinase PLK3

3

19

Small-scale

0.882

High

186181

PPM1D
Protein phosphatase 1D

2

10

Small-scale

0.825

High

302292

RNF8
E3 ubiquitin-protein ligase RNF8

2

11

Small-scale

0.819

High

186974

PPM1G
Protein phosphatase 1G

2

11

Small-scale

0.773

High

354902

CD11B
Cyclin-dependent kinase 11B

1

15

Small-scale

0.770

High

354914

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

Small-scale

0.759

High

354992

ELAV1
ELAV-like protein 1

1

7

Small-scale

0.756

High

240415

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

354920

BRCA1
Breast cancer type 1 susceptibility protein

8

7

Small-scale

0.751

High

354877

P53
Cellular tumor antigen p53

8

6

Small-scale

0.748

High

171145

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

Small-scale

0.747

High

354966

ATM
Serine-protein kinase ATM

6

20

Small-scale

0.736

High

354922

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.724

High

354979

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

Small-scale

0.724

High

355047

CD11A
Cyclin-dependent kinase 11A

1

15

Small-scale

0.715

High

354900

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

Small-scale

0.713

High

355023

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.710

High

191196

TLR3
Toll-like receptor 3

1

2

High-throughput

0.698

High

355027

RHBT2
Rho-related BTB domain-containing protein 2

1

15

High-throughput

0.698

High

355031

PRD14
PR domain zinc finger protein 14

1

1

High-throughput

0.698

High

354921

CDN1A
Cyclin-dependent kinase inhibitor 1

1

9

Small-scale

0.692

High

354924

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

354943

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.691

High

354948

FOXK1
Forkhead box protein K1

1

10

High-throughput

0.691

High

354952

FOXK2
Forkhead box protein K2

1

11

High-throughput

0.691

High

355041

RAI14
Ankycorbin

1

6

High-throughput

0.691

High

354942

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

15

Small-scale

0.686

High

354951

MDM2
E3 ubiquitin-protein ligase Mdm2

3

4

Small-scale

0.681

High

354937

ARP2
Actin-related protein 2

1

8

High-throughput

0.665

High

354947

PRKDC
DNA-dependent protein kinase catalytic subunit

3

20

Small-scale

0.655

High

354967

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

2

6

Small-scale

0.651

High

212627

DAPK3
Death-associated protein kinase 3

1

16

Small-scale

0.647

High

354946

SRPK2
SRSF protein kinase 2

1

19

High-throughput

0.647

High

355036

LATS2
Serine/threonine-protein kinase LATS2

1

15

Small-scale

0.647

High

354929

IMA1
Importin subunit alpha-1

2

2

Small-scale

0.646

High

354912

PML
Protein PML

2

8

Small-scale

0.646

High

355056

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

355032

P63
Tumor protein 63

2

6

High-throughput

0.628

High

250396

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

Small-scale

0.625

High

285764

SF3B1
Splicing factor 3B subunit 1

1

5

Small-scale

0.625

High

354899

CSK22
Casein kinase II subunit alpha'

1

16

Small-scale

0.625

High

354905

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

Small-scale

0.625

High

354925

RBM25
RNA-binding protein 25

1

8

Small-scale

0.625

High

354944

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.625

High

354954

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

16

Small-scale

0.625

High

354962

TADBP
TAR DNA-binding protein 43

1

11

Small-scale

0.625

High

354987

NONO
Non-POU domain-containing octamer-binding protein

1

13

Small-scale

0.625

High

354990

SF3B3
Splicing factor 3B subunit 3

1

3

Small-scale

0.625

High

355006

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

3

Small-scale

0.625

High

355025

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

9

Small-scale

0.625

High

355043

PUF60
Poly(U)-binding-splicing factor PUF60

1

4

Small-scale

0.625

High

354985

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

6

Small-scale

0.625

High

340959

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.625

High

354923

MSH2
DNA mismatch repair protein Msh2

2

1

Small-scale

0.624

High

182448

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.618

High

355001

MPRIP
Myosin phosphatase Rho-interacting protein

1

13

High-throughput

0.618

High

355005

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.618

High

355039

RBM28
RNA-binding protein 28

1

4

High-throughput

0.618

High

354970

SQSTM
Sequestosome-1

1

4

High-throughput

0.618

High

355034

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

354931

TERA
Transitional endoplasmic reticulum ATPase

2

4

Small-scale

0.612

High

354881

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.609

High

354928

BRCA2
Breast cancer type 2 susceptibility protein

3

0

Small-scale

0.608

High

354971

ATR
Serine/threonine-protein kinase ATR

2

20

Small-scale

0.602

High

355015

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

6

Small-scale

0.602

High

354891

XRCC5
X-ray repair cross-complementing protein 5

2

3

Small-scale

0.588

High

354898

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.583

High

354998

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

11

High-throughput

0.582

High

211527

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.578

High

354994

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

6

Small-scale

0.578

High

355040

AATF
Protein AATF

1

0

Small-scale

0.578

High

354975

FHL1
Four and a half LIM domains protein 1

1

5

Small-scale

0.573

High

354938

PSME3
Proteasome activator complex subunit 3

2

0

Small-scale

0.569

High

355020

MUS81
Structure-specific endonuclease subunit MUS81

1

4

Small-scale

0.561

High

355021

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.561

High

355019

LRAT2
Protein LRATD2

1

0

High-throughput

0.558

High

354935

PER3
Period circadian protein homolog 3

1

8

Small-scale

0.554

High

355049

PSF2
DNA replication complex GINS protein PSF2

1

2

Small-scale

0.554

High

354981

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

6

Small-scale

0.552

High

354986

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

6

Small-scale

0.552

High

354993

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

6

Small-scale

0.552

High

355053

STRAP
Serine-threonine kinase receptor-associated protein

1

4

Small-scale

0.550

High

354880

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.541

High

354882

ENOA
Alpha-enolase

1

5

High-throughput

0.541

High

354884

HXC6
Homeobox protein Hox-C6

1

3

High-throughput

0.541

High

354888

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.541

High

354892

CCL5
C-C motif chemokine 5

1

1

High-throughput

0.541

High

354897

STMN1
Stathmin

1

2

High-throughput

0.541

High

354933

CAD13
Cadherin-13

1

8

High-throughput

0.541

High

354934

ANM2
Protein arginine N-methyltransferase 2

1

3

High-throughput

0.541

High

354941

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

5

High-throughput

0.541

High

354955

RHG01
Rho GTPase-activating protein 1

1

3

High-throughput

0.541

High

355028

NSD3
Histone-lysine N-methyltransferase NSD3

1

2

High-throughput

0.541

High

355035

BEX1
Protein BEX1

1

1

High-throughput

0.541

High

355054

ST14
Suppressor of tumorigenicity 14 protein

1

3

High-throughput

0.541

High

354991

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

Small-scale

0.536

High

190783

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.536

High

227749

MYO1B
Unconventional myosin-Ib

1

15

High-throughput

0.536

High

244521

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

2

High-throughput

0.536

High

336306

SVIL
Supervillin

1

4

High-throughput

0.536

High

354876

FOS
Protein c-Fos

1

4

High-throughput

0.536

High

354883

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

354887

EPB41
Protein 4.1

1

5

High-throughput

0.536

High

354919

MYH10
Myosin-10

1

9

High-throughput

0.536

High

354959

TP53B
TP53-binding protein 1

1

2

Small-scale

0.536

High

354972

PWP1
Periodic tryptophan protein 1 homolog

1

12

High-throughput

0.536

High

354995

CYTSB
Cytospin-B

1

14

High-throughput

0.536

High

354999

CYTSA
Cytospin-A

1

12

High-throughput

0.536

High

355002

SV2A
Synaptic vesicle glycoprotein 2A

1

3

High-throughput

0.536

High

355008

SYT2
Synaptotagmin-2

1

1

High-throughput

0.536

High

355014

RAD50
DNA repair protein RAD50

1

18

Small-scale

0.536

High

355016

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

355024

DCR1C
Protein artemis

1

2

High-throughput

0.536

High

355029

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

355045

MYO5B
Unconventional myosin-Vb

1

9

High-throughput

0.536

High

355046

MYO6
Unconventional myosin-VI

1

11

High-throughput

0.536

High

354961

IL24
Interleukin-24

1

1

High-throughput

0.532

High

354976

FHL3
Four and a half LIM domains protein 3

1

8

Small-scale

0.527

High

354940

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.518

High

355011

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

High-throughput

0.518

High

355042

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.518

High

354953

CNTN2
Contactin-2

1

0

Small-scale

0.517

High

354894

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

355038

DCA13
DDB1- and CUL4-associated factor 13

1

3

High-throughput

0.515

High

354885

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

354984

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

179656

MDM4
Protein Mdm4

1

4

Small-scale

0.501

High

253224

REV3L
DNA polymerase zeta catalytic subunit

1

3

Small-scale

0.501

High

354878

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

354886

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.501

High

354956

FOXM1
Forkhead box protein M1

1

4

Small-scale

0.501

High

354926

KLK7
Kallikrein-7

1

3

High-throughput

0.494

High

355044

KLK9
Kallikrein-9

1

3

High-throughput

0.494

High

174683

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

3

High-throughput

0.489

High

342477

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

354910

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

3

High-throughput

0.489

High

354932

CAD12
Cadherin-12

1

7

High-throughput

0.489

High

354960

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

4

High-throughput

0.489

High

354964

KLRD1
Natural killer cells antigen CD94

1

4

High-throughput

0.489

High

224203

BUB3
Mitotic checkpoint protein BUB3

1

5

Small-scale

0.484

High

280449

PR40A
Pre-mRNA-processing factor 40 homolog A

1

9

Small-scale

0.484

High

333908

SMC2
Structural maintenance of chromosomes protein 2

1

8

Small-scale

0.484

High

354889

TPR
Nucleoprotein TPR

1

17

Small-scale

0.484

High

354893

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.484

High

354901

LMNB1
Lamin-B1

1

14

Small-scale

0.484

High

354906

MCM3
DNA replication licensing factor MCM3

1

14

Small-scale

0.484

High

354909

EF1G
Elongation factor 1-gamma

1

7

Small-scale

0.484

High

354913

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.484

High

354917

MCM5
DNA replication licensing factor MCM5

1

9

Small-scale

0.484

High

354918

MCM7
DNA replication licensing factor MCM7

1

10

Small-scale

0.484

High

354939

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

5

Small-scale

0.484

High

354950

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

Small-scale

0.484

High

354957

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.484

High

354958

AP1B1
AP-1 complex subunit beta-1

1

4

Small-scale

0.484

High

354977

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

13

Small-scale

0.484

High

354980

SMC1A
Structural maintenance of chromosomes protein 1A

1

10

Small-scale

0.484

High

354982

IMB1
Importin subunit beta-1

1

4

Small-scale

0.484

High

354983

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

Small-scale

0.484

High

354988

PCBP1
Poly(rC)-binding protein 1

1

4

Small-scale

0.484

High

354989

PCBP2
Poly(rC)-binding protein 2

1

5

Small-scale

0.484

High

354997

UBR4
E3 ubiquitin-protein ligase UBR4

1

7

Small-scale

0.484

High

355026

MBB1A
Myb-binding protein 1A

1

1

Small-scale

0.484

High

355030

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

Small-scale

0.484

High

355037

SMC4
Structural maintenance of chromosomes protein 4

1

8

Small-scale

0.484

High

355048

SMC3
Structural maintenance of chromosomes protein 3

1

10

Small-scale

0.484

High

355050

RUVB1
RuvB-like 1

1

1

Small-scale

0.484

High

354904

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

14

High-throughput

0.481

High

96596

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

159455

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

10

High-throughput

0.479

High

219675

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.479

High

325637

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

354890

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

354895

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

354896

H2AX
Histone H2AX

1

16

Small-scale

0.479

High

354907

RBTN2
Rhombotin-2

1

9

Small-scale

0.479

High

354908

RBTN1
Rhombotin-1

1

8

Small-scale

0.479

High

354911

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

354927

MXI1
Max-interacting protein 1

1

6

Small-scale

0.479

High

354936

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

354963

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

354965

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.479

High

354968

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.479

High

354973

CUL1
Cullin-1

1

9

Small-scale

0.479

High

354974

CUL4A
Cullin-4A

1

9

Small-scale

0.479

High

354978

FHL2
Four and a half LIM domains protein 2

1

8

Small-scale

0.479

High

355007

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

Small-scale

0.479

High

355010

LMO3
LIM domain only protein 3

1

8

Small-scale

0.479

High

355012

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

Small-scale

0.479

High

355013

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

355017

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

6

Small-scale

0.479

High

355018

CK5P3
CDK5 regulatory subunit-associated protein 3

1

1

Small-scale

0.479

High

355022

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

354903

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.464

High

354945

GTF2I
General transcription factor II-I

1

0

Small-scale

0.464

High

354969

SF3B2
Splicing factor 3B subunit 2

1

0

Small-scale

0.464

High

355009

FBX22
F-box only protein 22

1

0

Small-scale

0.464

High

355051

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

Small-scale

0.464

High

354949

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

Small-scale

0.439

High

355052

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.437

High

261993

NBN
Nibrin

1

0

Small-scale

0.414

High

354996

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.407

High

355003

SV2B
Synaptic vesicle glycoprotein 2B

1

6

High-throughput

0.407

High

332612

LYPD3
Ly6/PLAUR domain-containing protein 3

1

0

High-throughput

0.282

High

354879

CP17A
Steroid 17-alpha-hydroxylase/17,20 lyase

1

0

High-throughput

0.282

High

355004

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

0

High-throughput

0.282

High

355000

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

355055

CCG2
Voltage-dependent calcium channel gamma-2 subunit

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025