Protein: MPIP1
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)

Gene: MPIP1, CDC25A
Organism: Homo sapiens
Interactions: 126
UniProt ID: P30304

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163054

CHK1
Serine/threonine-protein kinase Chk1

9

3

Small-scale

0.972

High

354915

CHK2
Serine/threonine-protein kinase Chk2

6

4

Small-scale

0.948

High

667571

CDK2
Cyclin-dependent kinase 2

5

18

Small-scale

0.912

High

400351

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

5

Small-scale

0.866

High

719188

FBW1A
F-box/WD repeat-containing protein 1A

18

7

Small-scale

0.766

High

719184

FBW1B
F-box/WD repeat-containing protein 11

16

7

Small-scale

0.764

High

719174

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

Small-scale

0.740

High

719124

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.736

High

719125

SKP1
S-phase kinase-associated protein 1

6

1

Small-scale

0.730

High

719140

CUL1
Cullin-1

6

3

Small-scale

0.724

High

540987

PIM1
Serine/threonine-protein kinase pim-1

1

4

Small-scale

0.724

High

719123

1433E
14-3-3 protein epsilon

5

10

Small-scale

0.719

High

719132

1433F
14-3-3 protein eta

5

20

High-throughput

0.714

High

719107

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.705

High

719157

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

2

High-throughput

0.698

High

719170

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.698

High

690758

1433T
14-3-3 protein theta

4

20

Small-scale

0.697

High

719122

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

719137

DUS8
Dual specificity protein phosphatase 8

1

3

High-throughput

0.656

High

719186

FZR1
Fizzy-related protein homolog

3

2

Small-scale

0.656

High

719113

NAA10
N-alpha-acetyltransferase 10

2

1

Small-scale

0.654

High

666948

CCNE1
G1/S-specific cyclin-E1

3

11

Small-scale

0.651

High

573760

CCNB1
G2/mitotic-specific cyclin-B1

3

9

Small-scale

0.650

High

719115

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.647

High

719131

CDK5
Cyclin-dependent kinase 5

1

18

Small-scale

0.647

High

719138

ROCK1
Rho-associated protein kinase 1

1

1

Small-scale

0.647

High

719148

MK14
Mitogen-activated protein kinase 14

1

12

Small-scale

0.647

High

719134

EP300
Histone acetyltransferase p300

2

1

Small-scale

0.624

High

156993

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.618

High

443210

CDK1
Cyclin-dependent kinase 1

1

18

High-throughput

0.618

High

703450

MK01
Mitogen-activated protein kinase 1

1

5

High-throughput

0.618

High

719105

MPIP1
M-phase inducer phosphatase 1

1

3

High-throughput

0.618

High

719106

MPIP3
M-phase inducer phosphatase 3

1

3

Small-scale

0.618

High

719130

CDK3
Cyclin-dependent kinase 3

1

18

High-throughput

0.618

High

719150

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.618

High

719173

TRIB3
Tribbles homolog 3

1

1

Small-scale

0.618

High

719151

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.614

High

719175

NAA11
N-alpha-acetyltransferase 11

2

1

High-throughput

0.606

High

326927

UBE4B
Ubiquitin conjugation factor E4 B

2

0

High-throughput

0.602

High

719129

SMAD3
Mothers against decapentaplegic homolog 3

2

0

Small-scale

0.588

High

719168

AURKB
Aurora kinase B

1

0

High-throughput

0.586

High

719128

CCNA1
Cyclin-A1

2

8

Small-scale

0.584

High

719143

FHL1
Four and a half LIM domains protein 1

2

5

Small-scale

0.584

High

719180

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

1

High-throughput

0.584

High

362834

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.578

High

719167

HDA11
Histone deacetylase 11

1

3

Small-scale

0.578

High

719116

MAPK2
MAP kinase-activated protein kinase 2

1

2

Small-scale

0.575

High

717372

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.554

High

172497

XPO1
Exportin-1

1

5

High-throughput

0.541

High

681755

RBTN2
Rhombotin-2

1

4

High-throughput

0.541

High

719141

CUL3
Cullin-3

1

3

High-throughput

0.541

High

719144

CCNI
Cyclin-I

1

13

High-throughput

0.541

High

719146

IKBB
NF-kappa-B inhibitor beta

1

1

High-throughput

0.541

High

245675

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.518

High

391573

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

547414

DMD
Dystrophin

1

0

High-throughput

0.518

High

659656

NFYA
Nuclear transcription factor Y subunit alpha

1

0

High-throughput

0.518

High

719111

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.518

High

719112

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

719126

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

719136

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.518

High

719177

VAMP8
Vesicle-associated membrane protein 8

1

0

High-throughput

0.518

High

719182

FGF21
Fibroblast growth factor 21

1

0

High-throughput

0.518

High

719164

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

573004

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.513

High

187013

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

697778

CALR
Calreticulin

1

0

High-throughput

0.513

High

719179

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

719139

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

719172

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

421568

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

557125

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.480

High

133954

IPO5
Importin-5

1

2

High-throughput

0.479

High

229965

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.479

High

374422

RASH
GTPase HRas

1

1

Small-scale

0.479

High

629067

CCNA2
Cyclin-A2

1

8

High-throughput

0.479

High

719108

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

719109

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

719114

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

719117

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

719118

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

719119

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.479

High

719121

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.479

High

719133

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.479

High

719135

CDC20
Cell division cycle protein 20 homolog

1

2

High-throughput

0.479

High

719142

CUL4B
Cullin-4B

1

3

Small-scale

0.479

High

719152

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

719159

DJC10
DnaJ homolog subfamily C member 10

1

2

High-throughput

0.479

High

719162

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

719163

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

719165

TP4A1
Protein tyrosine phosphatase type IVA 1

1

3

High-throughput

0.479

High

719181

WDR6
tRNA

1

9

High-throughput

0.479

High

719191

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

Small-scale

0.479

High

175844

SET1A
Histone-lysine N-methyltransferase SETD1A

1

0

Small-scale

0.458

High

177177

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.458

High

188188

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

222752

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

316761

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

719110

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

719120

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

719127

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

719145

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.458

High

719147

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

719149

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

719153

DCAF8
DDB1- and CUL4-associated factor 8

1

0

Small-scale

0.458

High

719155

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.458

High

719156

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

719160

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

719161

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

719169

A7L3B
Ataxin-7-like protein 3B

1

0

High-throughput

0.458

High

719176

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.458

High

719178

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

719183

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.458

High

719187

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

719189

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

Small-scale

0.458

High

719190

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

719158

CC28A
Coiled-coil domain-containing protein 28A

1

1

High-throughput

0.437

High

719166

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

High-throughput

0.437

High

719171

APLD1
Apolipoprotein L domain-containing protein 1

1

1

High-throughput

0.437

High

719185

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.437

High

520756

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.282

High

689934

IL3RA
Interleukin-3 receptor subunit alpha

1

0

High-throughput

0.282

High

350650

DLGP3
Disks large-associated protein 3

1

0

High-throughput

0.249

Low

719154

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low

516820

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025