HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	31248990, 33961781, 35271311, unassigned3799
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 294
+	Hs
		288566 NSD2_HUMAN (1-1365): 0: 988: 100.00		NPM3_HUMAN (10-119): 6.16e-58: 185: 43.75
+	Hs
		447063 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		NPM_HUMAN (1-294): 1.76e-143: 406: 100.00
+	Hs
		447403 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		NPM_HUMAN (1-294): 1.76e-143: 406: 100.00
+	Hs
		446929 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		NPM_HUMAN (1-294): 1.76e-143: 406: 100.00
+	Hs
		447322 NSD1_HUMAN (69-658): 8.18e-26: 118: 14.33		NPM_HUMAN (1-294): 1.76e-143: 406: 100.00
+	Hs
		288659 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		NPM3_HUMAN (10-119): 6.16e-58: 185: 43.75