Protein: SETD2
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)

Gene: SETD2
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q9BYW2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005737 - cytoplasm
GO:0006298 - mismatch repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998772

H31
Histone H3.1

3

20

Small-scale

0.825

High

667435

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

9

Small-scale

0.806

High

1419386

WDR37
WD repeat-containing protein 37

2

8

High-throughput

0.789

High

1048088

TLE3
Transducin-like enhancer protein 3

2

7

High-throughput

0.754

High

170332

AURKA
Aurora kinase A

4

4

High-throughput

0.694

High

889655

CLK2
Dual specificity protein kinase CLK2

3

4

High-throughput

0.675

High

174269

ARHGA
Rho guanine nucleotide exchange factor 10

3

2

High-throughput

0.656

High

1162033

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

1419370

SETD2
Histone-lysine N-methyltransferase SETD2

1

19

Small-scale

0.647

High

843951

HD
Huntingtin

3

2

Small-scale

0.644

High

366263

FA9
Coagulation factor IX

2

1

High-throughput

0.628

High

1358659

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

2

High-throughput

0.628

High

1419373

NXF2
Nuclear RNA export factor 2

2

1

High-throughput

0.628

High

1419384

HSPB8
Heat shock protein beta-8

2

2

High-throughput

0.628

High

1331605

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

5

High-throughput

0.618

High

862424

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.618

High

980277

H4
Histone H4

1

7

High-throughput

0.618

High

1338943

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1387545

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.618

High

1419372

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.618

High

1419379

NLE1
Notchless protein homolog 1

1

3

High-throughput

0.618

High

1219049

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

1006684

SRPK2
SRSF protein kinase 2

2

6

High-throughput

0.601

High

1145351

RNPS1
RNA-binding protein with serine-rich domain 1

2

3

High-throughput

0.601

High

227660

SPOP
Speckle-type POZ protein

2

3

Small-scale

0.586

High

414560

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

1402988

IWS1
Protein IWS1 homolog

2

6

Small-scale

0.584

High

1014605

SMAD3
Mothers against decapentaplegic homolog 3

1

6

High-throughput

0.573

High

396878

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1400990

ARX
Homeobox protein ARX

1

4

High-throughput

0.541

High

134857

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.536

High

335503

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.536

High

478197

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.536

High

521430

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.536

High

542198

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

543540

VDR
Vitamin D3 receptor

1

20

High-throughput

0.536

High

562643

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.536

High

576532

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

3

High-throughput

0.536

High

872015

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.536

High

872718

SOX2
Transcription factor SOX-2

1

13

High-throughput

0.536

High

961214

FGF12
Fibroblast growth factor 12

1

1

High-throughput

0.536

High

995248

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.536

High

1065410

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.536

High

1099518

SRSF6
Serine/arginine-rich splicing factor 6

1

8

High-throughput

0.536

High

1115984

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

1127141

RBM39
RNA-binding protein 39

1

4

High-throughput

0.536

High

1149183

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.536

High

1160281

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.536

High

1239660

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

2

High-throughput

0.536

High

1314230

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.536

High

1335953

ZBT44
Zinc finger and BTB domain-containing protein 44

1

11

High-throughput

0.536

High

1341257

CTCFL
Transcriptional repressor CTCFL

1

1

High-throughput

0.536

High

1370574

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.536

High

1419377

CBX8
Chromobox protein homolog 8

1

20

High-throughput

0.536

High

1419383

CPNE7
Copine-7

1

2

High-throughput

0.536

High

447403

NPM
Nucleophosmin

1

3

High-throughput

0.515

High

883943

CENPF
Centromere protein F

1

9

High-throughput

0.515

High

66811

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

480300

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

574461

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

638601

ZNF10
Zinc finger protein 10

1

0

High-throughput

0.513

High

1122332

SCRIB
Protein scribble homolog

1

0

High-throughput

0.513

High

1154437

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

1419382

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

927529

ATX1
Ataxin-1

1

1

High-throughput

0.508

High

1401379

CIC
Protein capicua homolog

1

11

High-throughput

0.508

High

1417948

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.494

High

1009623

CXCL6
C-X-C motif chemokine 6

1

3

High-throughput

0.489

High

1308373

CCD71
Coiled-coil domain-containing protein 71

1

2

High-throughput

0.489

High

1398308

RN145
RING finger protein 145

1

3

High-throughput

0.489

High

211594

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

1

High-throughput

0.481

High

173318

XPO1
Exportin-1

1

1

High-throughput

0.479

High

174607

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.479

High

242829

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

260412

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

262566

MCE1
mRNA-capping enzyme

1

6

High-throughput

0.479

High

406610

MYCN
N-myc proto-oncogene protein

1

5

Small-scale

0.479

High

535499

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

620570

NUCL
Nucleolin

1

3

High-throughput

0.479

High

696423

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

697243

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

853398

CBX5
Chromobox protein homolog 5

1

20

High-throughput

0.479

High

855513

ATRX
Transcriptional regulator ATRX

1

15

Small-scale

0.479

High

905110

MECP2
Methyl-CpG-binding protein 2

1

10

High-throughput

0.479

High

1096808

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1097542

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1114214

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1128107

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.479

High

1129732

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.479

High

1135090

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1276746

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1281607

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

1313407

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1329851

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1357548

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1367202

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368602

KAT6A
Histone acetyltransferase KAT6A

1

9

High-throughput

0.479

High

1391742

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

1412811

PCGF1
Polycomb group RING finger protein 1

1

7

Small-scale

0.479

High

1414553

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

1416765

CECR2
Chromatin remodeling regulator CECR2

1

15

High-throughput

0.479

High

1419371

TRI31
E3 ubiquitin-protein ligase TRIM31

1

7

High-throughput

0.479

High

1419374

GAN
Gigaxonin

1

1

High-throughput

0.479

High

1419376

SP110
Sp110 nuclear body protein

1

14

High-throughput

0.479

High

1419380

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1419385

BRPF3
Bromodomain and PHD finger-containing protein 3

1

12

High-throughput

0.479

High

1419387

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

318872

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.470

High

1213470

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1289600

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

911366

IMA5
Importin subunit alpha-5

1

2

High-throughput

0.445

High

1419375

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1311848

DHX40
Probable ATP-dependent RNA helicase DHX40

1

5

High-throughput

0.437

High

96811

E9PB39
Rho guanine nucleotide exchange factor 10

1

2

High-throughput

0.407

High

1231140

SCAR3
Scavenger receptor class A member 3

3

0

High-throughput

0.347

High

260731

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

1059129

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

1178879

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1179028

S35G1
Solute carrier family 35 member G1

1

0

High-throughput

0.279

Low

1256465

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

1290411

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

0

High-throughput

0.279

Low

1340414

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.279

Low

1352894

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.279

Low

1410839

PSD2
PH and SEC7 domain-containing protein 2

1

0

High-throughput

0.279

Low

1419381

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1419388

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.279

Low

1419378

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.249

Low

1335709

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025