Protein: NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)

Gene: NSD1
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q96L73

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998694

H31
Histone H3.1

5

20

Small-scale

0.915

High

980157

H4
Histone H4

4

10

Small-scale

0.878

High

1163142

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.802

High

667411

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

Small-scale

0.724

High

1100967

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.692

High

502094

H2AZ
Histone H2A.Z

1

17

High-throughput

0.691

High

1194289

LARP7
La-related protein 7

1

14

High-throughput

0.691

High

550417

PABP1
Polyadenylate-binding protein 1

1

7

High-throughput

0.665

High

1372270

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

1162005

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

396731

ESR1
Estrogen receptor

3

20

Small-scale

0.636

High

517693

ZBT48
Zinc finger and BTB domain-containing protein 48

2

2

High-throughput

0.628

High

905043

MECP2
Methyl-CpG-binding protein 2

2

13

High-throughput

0.628

High

1396718

ZN692
Zinc finger protein 692

2

7

High-throughput

0.628

High

883661

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

981018

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

1017124

H33
Histone H3.3

1

20

High-throughput

0.618

High

1097495

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1141267

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

1338903

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1396719

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

9

High-throughput

0.618

High

596301

H12
Histone H1.2

2

16

Small-scale

0.611

High

520299

ANDR
Androgen receptor

2

20

Small-scale

0.609

High

465070

ZFY
Zinc finger Y-chromosomal protein

2

0

High-throughput

0.602

High

1045651

TF65
Transcription factor p65

2

8

Small-scale

0.601

High

601810

HMGA1
High mobility group protein HMG-I/HMG-Y

2

2

High-throughput

0.588

High

1396717

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

1396725

G3BP2
Ras GTPase-activating protein-binding protein 2

1

6

High-throughput

0.579

High

1180767

CEA16
Cell adhesion molecule CEACAM16

1

0

High-throughput

0.578

High

1394377

ZN496
Zinc finger protein 496

1

11

Small-scale

0.573

High

353509

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.553

High

191754

MAGB2
Melanoma-associated antigen B2

1

8

High-throughput

0.536

High

447322

NPM
Nucleophosmin

1

5

High-throughput

0.536

High

785366

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

978663

RL23A
Large ribosomal subunit protein uL23

1

5

High-throughput

0.536

High

1089807

ILF3
Interleukin enhancer-binding factor 3

1

10

High-throughput

0.536

High

1281443

ZN467
Zinc finger protein 467

1

1

High-throughput

0.536

High

1385970

ZN653
Zinc finger protein 653

1

7

High-throughput

0.536

High

521865

H14
Histone H1.4

1

16

High-throughput

0.515

High

1396716

YTDC1
YTH domain-containing protein 1

1

1

High-throughput

0.515

High

1227270

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.514

High

1396722

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

595560

H15
Histone H1.5

1

18

Small-scale

0.501

High

595847

H13
Histone H1.3

1

16

Small-scale

0.501

High

855497

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.501

High

1371605

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.501

High

301171

RL1D1
Ribosomal L1 domain-containing protein 1

1

3

High-throughput

0.489

High

657287

KALM
Anosmin-1

1

2

High-throughput

0.489

High

1396729

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.489

High

284513

TNR21
Tumor necrosis factor receptor superfamily member 21

1

2

Small-scale

0.481

High

137546

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.481

High

520624

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.481

High

522790

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.481

High

522830

COT1
COUP transcription factor 1

1

20

Small-scale

0.481

High

533359

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.481

High

543532

VDR
Vitamin D3 receptor

1

20

Small-scale

0.481

High

543589

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.481

High

625839

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.481

High

665129

COT2
COUP transcription factor 2

1

20

Small-scale

0.481

High

771013

RORA
Nuclear receptor ROR-alpha

1

20

Small-scale

0.481

High

789556

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.481

High

1127877

HNF4G
Hepatocyte nuclear factor 4-gamma

1

20

Small-scale

0.481

High

1148266

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

20

Small-scale

0.481

High

1201925

Q58EY0
RAR related orphan receptor B isoform 1

1

20

Small-scale

0.481

High

1396730

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

Small-scale

0.481

High

141056

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

143196

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

191052

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

386110

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.479

High

430247

JUN
Transcription factor Jun

1

7

High-throughput

0.479

High

464285

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

474216

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487640

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

558334

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

589435

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696241

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

697221

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

768919

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

800056

COIL
Coilin

1

4

High-throughput

0.479

High

862384

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

872641

SOX2
Transcription factor SOX-2

1

20

Small-scale

0.479

High

984910

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

1035848

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1087951

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1115363

CUL4B
Cullin-4B

1

12

Small-scale

0.479

High

1129701

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.479

High

1133610

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1144127

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.479

High

1276651

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1281588

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

1313342

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1367041

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1396720

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1396721

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1396723

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1396724

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1396727

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

1396728

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1157032

NTRK3
NT-3 growth factor receptor

1

4

Small-scale

0.439

High

365449

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.437

High

643542

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

2

High-throughput

0.437

High

665484

EF1B
Elongation factor 1-beta

1

3

High-throughput

0.437

High

908291

AFF1
AF4/FMR2 family member 1

1

11

Small-scale

0.437

High

992058

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.437

High

1311833

DHX40
Probable ATP-dependent RNA helicase DHX40

1

9

High-throughput

0.437

High

1139995

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.426

High

1396726

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.407

High

70425

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1186686

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1295764

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025