HitPredict

Interactor 1: CRYAA (P02489)
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) (Heat shock protein family B member 4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)]
Gene: CRYAA

Interactor 2: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 25416956, 22085609, 26657544, 28919577, 11700327, 12601044, 18401461, 22427585, 18639655, 25694240, 25910212, 32296183, 16142923, 17260942, 16760894, 23188086, 19651604, 22153508, unassigned1304
Identification Methods two hybrid, pull down, fluorescent resonance energy transfer, affinity chromatography technology, molecular sieving, cosedimentation in solution, dynamic light scattering, mass spectrometry studies of complexes, transmission electron microscopy, validated two hybrid and 8 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Crystallin~Crystallin, Crystallin~HSP20, HSP20~HSP20
Common GO terms GO:0002088 - lens development in camera-type eye
GO:0005198 - structural molecule activity
GO:0005212 - structural constituent of eye lens
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 10 others

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Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 173
Hs

1 175
+ Hs
+ Bt
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024