HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: CRGD (P07320)
Gamma-crystallin D (Gamma-D-crystallin) (Gamma-crystallin 4)
Gene: CRYGD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	12601044, 21173272, 16274233, 22655036
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 174
+	Hs
		358955 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRGC_HUMAN (1-173): 4.13e-97: 279: 71.68
+	Hs
		358971 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRYGS_HUMAN (3-172): 1.62e-85: 250: 50.00
+	Hs
		358702 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRGC_HUMAN (1-173): 4.13e-97: 279: 71.68
+	Hs
		388156 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CRGC_HUMAN (1-173): 4.13e-97: 279: 71.68
+	Hs
		358703 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRGD_HUMAN (1-174): 1.52e-94: 273: 100.00
+	Hs
		426907 HSPB2_HUMAN (15-149): 2.86e-39: 133: 42.96		CRGC_HUMAN (1-173): 4.13e-97: 279: 71.68
+	Hs
		358985 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRBB2_HUMAN (83-170): 1.32e-19: 83.4: 28.89
+	Hs
		358953 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRBA1_HUMAN (2-83): 4.02e-18: 79.5: 32.97
+	Hs
		358725 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBB2_HUMAN (83-170): 1.32e-19: 83.4: 28.89
+	Hs
		358714 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBB3_HUMAN (86-170): 2.16e-18: 80.3: 32.18
+	Hs
		358701 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBA1_HUMAN (2-83): 4.02e-18: 79.5: 32.97
+	Hs
		388287 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CRBB2_HUMAN (83-170): 1.32e-19: 83.4: 28.89
+	Hs
		358733 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBA4_HUMAN (2-77): 2.73e-12: 63.7: 30.12