HitPredict

Interactor 1: K1C14 (P02533)
Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)
Gene: KRT14

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045110 - intermediate filament bundle assembly and 1 others more... GO:1990254 - keratin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 472 Hs			1 5088
+	Hs
		885266 K1C27_HUMAN (31-472): 2.58e-142: 417: 51.23		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885254 K1H1_HUMAN (75-441): 4.71e-138: 405: 53.93		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885247 KT33B_HUMAN (108-443): 3.43e-125: 371: 57.44		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		213934 KRT86_HUMAN (7-434): 1.14e-97: 304: 24.71		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885269 K2C73_HUMAN (2-429): 6.97e-95: 298: 26.28		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		318791 K2C75_HUMAN (3-437): 1.6e-87: 279: 27.46		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885321 KRT82_HUMAN (5-439): 1.95e-87: 278: 26.15		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Rn
		513772 K1C19_RAT (56-428): 1.75e-138: 405: 64.34		DMD_RAT (1908-3539): 9.79e-136: 484: 10.58
+	Hs
		445052 K1C16_HUMAN (1-441): 3.53e-146: 427: 84.42		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		444372 K1C19_HUMAN (104-428): 1.03e-145: 424: 69.23		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		280584 KRT34_HUMAN (108-426): 1.34e-121: 362: 58.31		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		359355 K1C14_HUMAN (1-472): 9.98e-121: 362: 100.00		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		444307 K1C19_HUMAN (104-428): 1.03e-145: 424: 69.23		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		551676 K1C17_HUMAN (108-470): 1.08e-144: 422: 82.37		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		444425 K1C19_HUMAN (104-428): 1.03e-145: 424: 69.23		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		974058 K1C17_HUMAN (108-470): 1.08e-144: 422: 82.37		DYST_HUMAN (251-3746): 3.34e-15: 85.9: 10.46
+	Hs
		1189645 K1C27_HUMAN (31-472): 2.58e-142: 417: 51.23		CP250_HUMAN (2024-3653): 8.35e-15: 84.4: 10.70
+	Hs
		444301 K1C19_HUMAN (104-428): 1.03e-145: 424: 69.23		DMD_HUMAN (1909-3327): 6.13e-09: 65.1: 11.08
+	Hs
		1071210 K1H1_HUMAN (75-441): 4.71e-138: 405: 53.93		MYOME_HUMAN (2672-3762): 2.03e-12: 76.7: 12.20
+	Hs
		234240 K1C25_HUMAN (109-446): 1.35e-119: 359: 57.60		PEPL_HUMAN (2575-3932): 2.76e-26: 122: 10.40