HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: ZN444 (Q8N0Y2)
Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17)
Gene: ZNF444

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	33961781, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 327
+	Hs
		360070 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZFP2_HUMAN (66-321): 4.26e-102: 309: 19.70
+	Hs
		360385 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZN436_HUMAN (164-321): 7.77e-73: 234: 31.58
+	Hs
		595299 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		ZN444_HUMAN (1-302): 2.05e-104: 310: 100.00
+	Hs
		359633 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZNF3_HUMAN (4-234): 5.35e-51: 176: 20.25
+	Hs
		200800 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZSC12_HUMAN (66-314): 9.12e-49: 174: 23.31
+	Hs
		67847 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZN724_HUMAN (4-149): 7.48e-49: 174: 10.74
+	Hs
		360243 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZKSC4_HUMAN (169-308): 4.59e-49: 173: 31.58
+	Hs
		535468 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZN444_HUMAN (1-302): 2.05e-104: 310: 100.00
+	Hs
		535603 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZN232_HUMAN (15-306): 2.01e-93: 286: 30.81
+	Hs
		182406 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZSC9_HUMAN (9-301): 6.98e-92: 280: 30.95
+	Hs
		359978 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZKSC8_HUMAN (10-153): 7.37e-34: 132: 37.67
+	Hs
		359631 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZKSC1_HUMAN (9-178): 7.14e-32: 126: 34.71
+	Hs
		360017 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZN569_HUMAN (4-144): 1.68e-31: 126: 12.25
+	Hs
		359594 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZSC22_HUMAN (243-322): 3.61e-20: 92.6: 31.25
+	Hs
		535557 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZN436_HUMAN (164-321): 7.77e-73: 234: 31.58
+	Hs
		360580 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		ZSC21_HUMAN (78-177): 3.59e-13: 71.8: 12.00
+	Hs
		230678 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZN500_HUMAN (81-318): 1.3e-55: 189: 26.92
+	Hs
		535320 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZNF19_HUMAN (216-314): 1.52e-25: 107: 30.30
+	Hs
		485160 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZSC22_HUMAN (243-322): 3.61e-20: 92.6: 31.25
+	Hs
		535608 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ZKSC5_HUMAN (181-277): 7.08e-09: 58.9: 31.96