Protein: NOS3
Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)

Gene: NOS3
Organism: Homo sapiens
Interactions: 99
UniProt ID: P29474

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001525 - angiogenesis
GO:0001542 - ovulation from ovarian follicle
GO:0001701 - in utero embryonic development
GO:0001974 - blood vessel remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

713068

NOS3
Nitric oxide synthase 3

7

9

Small-scale

0.948

High

713071

ACTN2
Alpha-actinin-2

2

2

Small-scale

0.762

High

461181

HS90A
Heat shock protein HSP 90-alpha

6

5

Small-scale

0.732

High

713081

HBA
Hemoglobin subunit alpha

1

1

Small-scale

0.724

High

713085

CAV1
Caveolin-1

4

4

Small-scale

0.683

High

713087

GOGA2
Golgin subfamily A member 2

3

1

High-throughput

0.675

High

713145

NOSIP
Nitric oxide synthase-interacting protein

2

1

Small-scale

0.631

High

713116

NOSTN
Nostrin

2

0

Small-scale

0.617

High

224631

ACTN4
Alpha-actinin-4

2

2

Small-scale

0.614

High

713139

IKZF3
Zinc finger protein Aiolos

2

1

High-throughput

0.606

High

713069

AKT1
RAC-alpha serine/threonine-protein kinase

2

3

Small-scale

0.595

High

713123

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.590

High

713075

F10A1
Hsc70-interacting protein

1

4

High-throughput

0.581

High

713096

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.574

High

713084

GCYB1
Guanylate cyclase soluble subunit beta-1

1

1

Small-scale

0.561

High

713070

CTNB1
Catenin beta-1

2

0

Small-scale

0.559

High

713078

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.554

High

713072

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.549

High

713095

ELAV1
ELAV-like protein 1

1

3

High-throughput

0.541

High

713143

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.541

High

421559

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.529

High

713103

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

High-throughput

0.518

High

713121

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.518

High

713130

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.518

High

713133

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

713125

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.515

High

62324

A4FUJ8
MKL1 protein

1

1

High-throughput

0.515

High

188436

NVL
Nuclear valosin-containing protein-like

1

3

High-throughput

0.515

High

297464

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.515

High

318953

MICA2
[F-actin]-monooxygenase MICAL2

1

4

High-throughput

0.515

High

713076

RBM11
Splicing regulator RBM11

1

4

High-throughput

0.515

High

713079

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

High-throughput

0.515

High

713092

KT33B
Keratin, type I cuticular Ha3-II

1

1

High-throughput

0.515

High

713102

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

6

High-throughput

0.515

High

713110

H32
Histone H3.2

1

2

High-throughput

0.515

High

713111

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

1

High-throughput

0.515

High

713112

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

713113

TRI69
E3 ubiquitin-protein ligase TRIM69

1

2

High-throughput

0.515

High

713134

UBQL3
Ubiquilin-3

1

4

High-throughput

0.515

High

713138

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.515

High

713140

CSN3
COP9 signalosome complex subunit 3

1

3

High-throughput

0.515

High

713144

KLH20
Kelch-like protein 20

1

1

High-throughput

0.515

High

713082

H33
Histone H3.3

1

2

High-throughput

0.508

High

713106

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.508

High

713126

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.508

High

387377

APOE
Apolipoprotein E

1

0

High-throughput

0.504

High

395551

ESR1
Estrogen receptor

1

5

Small-scale

0.500

High

713093

ELAV3
ELAV-like protein 3

1

3

High-throughput

0.494

High

185163

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.493

High

713077

VSX2
Visual system homeobox 2

1

0

High-throughput

0.493

High

713080

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.493

High

713089

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.493

High

713097

PCSK7
Proprotein convertase subtilisin/kexin type 7

1

0

High-throughput

0.493

High

713104

LEG9C
Galectin-9C

1

0

High-throughput

0.493

High

713107

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

1

0

High-throughput

0.493

High

713114

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.493

High

713115

SPA2L
Spermatogenesis-associated protein 2-like protein

1

0

High-throughput

0.493

High

713120

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.493

High

713127

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.493

High

713128

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

0

High-throughput

0.493

High

713129

ST4A1
Sulfotransferase 4A1

1

0

High-throughput

0.493

High

713131

REXO4
RNA exonuclease 4

1

0

High-throughput

0.493

High

713132

SKI8
Superkiller complex protein 8

1

0

High-throughput

0.493

High

713135

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

0

High-throughput

0.493

High

713136

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.493

High

713141

ZN232
Zinc finger protein 232

1

0

High-throughput

0.493

High

713148

ASB3
Ankyrin repeat and SOCS box protein 3

1

0

High-throughput

0.493

High

539035

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.486

High

713122

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.486

High

713147

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.486

High

713090

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.484

High

713073

PSN1
Presenilin-1

1

1

High-throughput

0.481

High

713074

PSN2
Presenilin-2

1

1

High-throughput

0.481

High

713109

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.481

High

627268

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

7

Small-scale

0.479

High

661226

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

7

Small-scale

0.479

High

713083

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

5

Small-scale

0.479

High

713086

DYN1
Dynamin-1

1

1

Small-scale

0.479

High

713091

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

713142

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

Small-scale

0.479

High

351506

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

2

High-throughput

0.464

High

713088

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

2

High-throughput

0.464

High

713105

TXD11
Thioredoxin domain-containing protein 11

1

1

High-throughput

0.464

High

713099

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.460

High

713137

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.460

High

713146

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.460

High

188186

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

640773

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

Small-scale

0.458

High

713094

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

713100

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

369624

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.282

High

713101

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.268

Low

713108

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

713117

MPND
MPN domain-containing protein

1

0

High-throughput

0.268

Low

713118

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.268

Low

713119

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.268

Low

713124

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

713098

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025