HitPredict

Interactor 1: PROF1 (P02584)
Profilin-1 (Profilin I)
Gene: PFN1

Interactor 2: ACTB (P60712)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8413665
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Profilin
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 140 Bt			1 375
+	Hs
		714971 PROF2_HUMAN (1-140): 2.66e-73: 216: 62.14		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		891642 PROF3_HUMAN (1-139): 5e-64: 193: 41.73		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		430115 PROF1_HUMAN (1-140): 8.78e-78: 228: 95.00		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Mm
		892155 PROF1_MOUSE (1-140): 6.53e-78: 228: 96.43		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Hs
		430128 PROF1_HUMAN (1-140): 8.78e-78: 228: 95.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Bt
		361200 PROF1_BOVIN (1-140): 1.55e-78: 230: 100.00		ACTS_BOVIN (2-375): 0: 592: 93.58
+	Hs
		430130 PROF1_HUMAN (1-140): 8.78e-78: 228: 95.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Mm
		892215 PROF2_MOUSE (1-140): 2.21e-73: 217: 62.14		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Hs
		430125 PROF1_HUMAN (1-140): 8.78e-78: 228: 95.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		714946 PROF2_HUMAN (1-140): 2.66e-73: 216: 62.14		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		714953 PROF2_HUMAN (1-140): 2.66e-73: 216: 62.14		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		714954 PROF2_HUMAN (1-140): 2.66e-73: 216: 62.14		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		714951 PROF2_HUMAN (1-140): 2.66e-73: 216: 62.14		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		891639 PROF3_HUMAN (1-139): 5e-64: 193: 41.73		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891641 PROF3_HUMAN (1-139): 5e-64: 193: 41.73		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		891640 PROF3_HUMAN (1-139): 5e-64: 193: 41.73		ACTA_HUMAN (2-375): 0: 591: 94.12