Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.70 | 1.00 | 0.839 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20029029, unassigned2173, 24658140 |
| Identification Methods | protein complementation assay, ubiquitin reconstruction |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cofilin_ADF~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion and 7 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
