HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HSPA9 (P38646)
Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	24189400, 28065597, unassigned2173, 15657067
Identification Methods	affinity chromatography technology, ubiquitin reconstruction, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 679
+	Hs
		363381 EGFR_HUMAN (1-1210): 0: 1246: 100.00		Q59EJ3_HUMAN (4-652): 0: 905: 46.53
+	Hs
		362860 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HS71L_HUMAN (49-673): 0: 883: 47.59
+	Hs
		362666 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HSP7C_HUMAN (51-653): 0: 882: 50.16
+	Hs
		363377 EGFR_HUMAN (1-1210): 0: 1246: 100.00		Q53GZ6_HUMAN (51-653): 0: 880: 50.00
+	Hs
		362654 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HS71A_HUMAN (51-652): 0: 872: 49.27
+	Hs
		363375 EGFR_HUMAN (1-1210): 0: 1246: 100.00		Q53FC7_HUMAN (49-673): 0: 870: 48.37
+	Hs
		363029 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HSP72_HUMAN (50-653): 0: 867: 49.11
+	Hs
		410677 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		HSPA9_HUMAN (1-679): 0: 873: 100.00
+	Hs
		410884 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		Q53FC7_HUMAN (49-673): 0: 870: 48.37
+	Hs
		536492 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		HSP7C_HUMAN (51-653): 0: 882: 50.16
+	Hs
		362665 EGFR_HUMAN (1-1210): 0: 1246: 100.00		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		410555 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		534627 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		536565 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		HSP7C_HUMAN (51-653): 0: 882: 50.16
+	Hs
		465381 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		HSP7C_HUMAN (51-653): 0: 882: 50.16
+	Hs
		463888 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		534683 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		535093 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		465380 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		BIP_HUMAN (53-677): 0: 566: 50.55
+	Rn
		448088 INSR_RAT (579-1032): 3.03e-104: 361: 23.87		BIP_RAT (53-677): 0: 567: 51.97