Protein: EPHB2
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]

Gene: EPHB2
Organism: Homo sapiens
Interactions: 195
UniProt ID: P29323

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001540 - amyloid-beta binding
GO:0001655 - urogenital system development
GO:0002639 - positive regulation of immunoglobulin production
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

710796

EFNB2
Ephrin-B2

6

20

Small-scale

0.944

High

710076

EPHA2
Ephrin type-A receptor 2

3

19

Small-scale

0.847

High

557121

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.828

High

635678

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.812

High

710810

EFNB1
Ephrin-B1

2

20

High-throughput

0.776

High

410645

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.757

High

710789

ABL2
Tyrosine-protein kinase ABL2

2

20

Small-scale

0.757

High

710782

EPHB2
Ephrin type-B receptor 2

2

18

Small-scale

0.755

High

362174

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.740

High

710603

EPHA3
Ephrin type-A receptor 3

1

17

Small-scale

0.724

High

710799

EPHA4
Ephrin type-A receptor 4

1

18

High-throughput

0.715

High

456135

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

High-throughput

0.691

High

710837

EPHA7
Ephrin type-A receptor 7

1

18

High-throughput

0.691

High

710842

CDC37
Hsp90 co-chaperone Cdc37

1

17

High-throughput

0.691

High

710881

PSKH2
Serine/threonine-protein kinase H2

1

13

High-throughput

0.691

High

710899

PICK1
PRKCA-binding protein

1

4

High-throughput

0.691

High

710884

SPSB2
SPRY domain-containing SOCS box protein 2

4

13

High-throughput

0.691

High

710800

AFAD
Afadin

1

20

Small-scale

0.656

High

710874

SPSB4
SPRY domain-containing SOCS box protein 4

3

13

Small-scale

0.650

High

421554

A4
Amyloid-beta precursor protein

1

11

Small-scale

0.647

High

462999

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

710791

CRK
Adapter molecule crk

1

20

Small-scale

0.647

High

710797

EPHB3
Ephrin type-B receptor 3

1

18

High-throughput

0.646

High

710798

EPHB1
Ephrin type-B receptor 1

1

19

High-throughput

0.646

High

710808

RAE1L
mRNA export factor RAE1

1

2

High-throughput

0.646

High

710910

EPHA6
Ephrin type-A receptor 6

1

18

High-throughput

0.646

High

618987

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

9

Small-scale

0.621

High

710879

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

1

20

High-throughput

0.618

High

710915

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.618

High

287871

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

2

High-throughput

0.618

High

504709

FBSP1
F-box/SPRY domain-containing protein 1

2

16

High-throughput

0.618

High

67621

RHG32
Rho GTPase-activating protein 32

1

20

High-throughput

0.618

High

136302

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

181781

EPHB6
Ephrin type-B receptor 6

1

17

Small-scale

0.618

High

269516

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

16

High-throughput

0.618

High

348060

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

375210

RASK
GTPase KRas

1

20

High-throughput

0.618

High

635238

EFNA1
Ephrin-A1

1

20

High-throughput

0.618

High

683779

MOES
Moesin

1

18

High-throughput

0.618

High

691999

MARK3
MAP/microtubule affinity-regulating kinase 3

1

10

High-throughput

0.618

High

699598

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

710783

RYK
Tyrosine-protein kinase RYK

1

20

Small-scale

0.618

High

710785

MERL
Merlin

1

19

High-throughput

0.618

High

710786

RADI
Radixin

1

18

High-throughput

0.618

High

710801

RAB2A
Ras-related protein Rab-2A

1

15

High-throughput

0.618

High

710804

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

710805

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

710812

ANK2
Ankyrin-2

1

7

High-throughput

0.618

High

710815

NOTC2
Neurogenic locus notch homolog protein 2

1

13

High-throughput

0.618

High

710820

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

710821

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

High-throughput

0.618

High

710822

ANK3
Ankyrin-3

1

7

High-throughput

0.618

High

710823

TP4A2
Protein tyrosine phosphatase type IVA 2

1

12

High-throughput

0.618

High

710826

ROCK1
Rho-associated protein kinase 1

1

9

High-throughput

0.618

High

710827

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

710828

STIM1
Stromal interaction molecule 1

1

8

High-throughput

0.618

High

710831

SCRIB
Protein scribble homolog

1

20

High-throughput

0.618

High

710833

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

710836

RAB35
Ras-related protein Rab-35

1

15

High-throughput

0.618

High

710840

ITSN1
Intersectin-1

1

15

Small-scale

0.618

High

710846

PDZ11
PDZ domain-containing protein 11

1

20

High-throughput

0.618

High

710848

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

710850

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

16

High-throughput

0.618

High

710861

UNC5B
Netrin receptor UNC5B

1

15

High-throughput

0.618

High

710862

ABI1
Abl interactor 1

1

20

High-throughput

0.618

High

710864

EHBP1
EH domain-binding protein 1

1

13

High-throughput

0.618

High

710866

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.618

High

710875

FERM2
Fermitin family homolog 2

1

4

High-throughput

0.618

High

710876

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.618

High

710880

ASPP1
Apoptosis-stimulating of p53 protein 1

1

12

High-throughput

0.618

High

710889

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

15

High-throughput

0.618

High

710892

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

14

High-throughput

0.618

High

710894

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

710895

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

710896

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

710901

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.618

High

710913

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

18

High-throughput

0.618

High

710914

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.618

High

710916

ALK
ALK tyrosine kinase receptor

1

18

Small-scale

0.618

High

710917

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

10

High-throughput

0.618

High

710922

GIT1
ARF GTPase-activating protein GIT1

1

13

Small-scale

0.618

High

710904

RN186
E3 ubiquitin-protein ligase RNF186

1

1

Small-scale

0.586

High

710806

TBA1B
Tubulin alpha-1B chain

1

11

High-throughput

0.553

High

710868

CSKI2
Caskin-2

1

16

High-throughput

0.553

High

710863

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

2

High-throughput

0.541

High

534683

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.536

High

710809

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.536

High

710794

NU153
Nuclear pore complex protein Nup153

1

5

Small-scale

0.527

High

710824

TADBP
TAR DNA-binding protein 43

1

5

High-throughput

0.515

High

710855

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

710869

JPH3
Junctophilin-3

1

7

High-throughput

0.515

High

710888

TRI54
Tripartite motif-containing protein 54

1

16

High-throughput

0.504

High

710923

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

285598

BAF
Barrier-to-autointegration factor

1

5

High-throughput

0.500

High

710790

EAA1
Excitatory amino acid transporter 1

1

13

High-throughput

0.500

High

710802

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

710811

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.500

High

710835

OZF
Zinc finger protein OZF

1

4

High-throughput

0.500

High

710857

DYH10
Dynein axonemal heavy chain 10

1

7

High-throughput

0.500

High

710860

TRM2A
tRNA

1

2

High-throughput

0.500

High

710865

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

3

High-throughput

0.500

High

710870

S39A7
Zinc transporter SLC39A7

1

7

High-throughput

0.500

High

710885

NTPCR
Cancer-related nucleoside-triphosphatase

1

7

High-throughput

0.500

High

710887

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.500

High

710900

MDN1
Midasin

1

13

High-throughput

0.500

High

710902

FANCI
Fanconi anemia group I protein

1

3

High-throughput

0.500

High

165759

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.493

High

642197

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.493

High

71705

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.479

High

154466

CLD4
Claudin-4

1

2

Small-scale

0.479

High

158121

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.479

High

169450

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

178722

SCAM1
Secretory carrier-associated membrane protein 1

1

3

High-throughput

0.479

High

192198

YKT6
Synaptobrevin homolog YKT6

1

7

High-throughput

0.479

High

217866

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

229961

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

276277

HMMR
Hyaluronan mediated motility receptor

1

8

Small-scale

0.479

High

338294

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.479

High

338430

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.479

High

343320

SNP29
Synaptosomal-associated protein 29

1

5

High-throughput

0.479

High

426206

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.479

High

536565

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

566564

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.479

High

577630

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

636995

VATB2
V-type proton ATPase subunit B, brain isoform

1

3

High-throughput

0.479

High

666072

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

3

Small-scale

0.479

High

704914

RBL1
Retinoblastoma-like protein 1

1

3

High-throughput

0.479

High

710784

CTNB1
Catenin beta-1

1

18

High-throughput

0.479

High

710787

ADDB
Beta-adducin

1

6

High-throughput

0.479

High

710792

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

5

High-throughput

0.479

High

710793

NUMB
Protein numb homolog

1

16

High-throughput

0.479

High

710795

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

8

High-throughput

0.479

High

710803

ARF6
ADP-ribosylation factor 6

1

13

High-throughput

0.479

High

710807

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

710813

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

710814

CAV1
Caveolin-1

1

8

High-throughput

0.479

High

710816

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

Small-scale

0.479

High

710817

KLC1
Kinesin light chain 1

1

3

High-throughput

0.479

High

710818

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

4

High-throughput

0.479

High

710819

FCHO2
F-BAR domain only protein 2

1

11

High-throughput

0.479

High

710825

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

Small-scale

0.479

High

710832

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

High-throughput

0.479

High

710834

DIP2A
Disco-interacting protein 2 homolog A

1

9

High-throughput

0.479

High

710838

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.479

High

710839

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.479

High

710841

VAMP3
Vesicle-associated membrane protein 3

1

5

High-throughput

0.479

High

710843

OCLN
Occludin

1

6

High-throughput

0.479

High

710844

TB10B
TBC1 domain family member 10B

1

13

High-throughput

0.479

High

710847

F1711
Protein FAM171A1

1

10

High-throughput

0.479

High

710849

GRIN3
G protein-regulated inducer of neurite outgrowth 3

1

5

High-throughput

0.479

High

710851

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

9

High-throughput

0.479

High

710853

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

14

High-throughput

0.479

High

710854

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.479

High

710856

LSR
Lipolysis-stimulated lipoprotein receptor

1

4

High-throughput

0.479

High

710858

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.479

High

710867

BRK1
Protein BRICK1

1

3

High-throughput

0.479

High

710871

WASF1
Actin-binding protein WASF1

1

19

High-throughput

0.479

High

710872

SEPT8
Septin-8

1

14

High-throughput

0.479

High

710873

US6NL
USP6 N-terminal-like protein

1

11

High-throughput

0.479

High

710877

SPSB1
SPRY domain-containing SOCS box protein 1

1

13

Small-scale

0.479

High

710878

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

9

High-throughput

0.479

High

710882

NIBA2
Protein Niban 2

1

6

High-throughput

0.479

High

710883

CDCA3
Cell division cycle-associated protein 3

1

7

High-throughput

0.479

High

710886

RFIP5
Rab11 family-interacting protein 5

1

5

High-throughput

0.479

High

710905

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

5

Small-scale

0.479

High

710909

DIP2B
Disco-interacting protein 2 homolog B

1

10

High-throughput

0.479

High

710918

BAIP2
BAR/IMD domain-containing adapter protein 2

1

19

High-throughput

0.479

High

710919

NCKP1
Nck-associated protein 1

1

2

High-throughput

0.479

High

710920

NISCH
Nischarin

1

20

High-throughput

0.479

High

710924

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

710926

WASF2
Actin-binding protein WASF2

1

17

High-throughput

0.479

High

710788

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

9

High-throughput

0.457

High

710891

ZDHC6
Palmitoyltransferase ZDHHC6

1

8

High-throughput

0.457

High

710897

TM9S3
Transmembrane 9 superfamily member 3

1

2

High-throughput

0.457

High

710907

HACD3
Very-long-chain

1

5

High-throughput

0.457

High

254826

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

349381

TSN15
Tetraspanin-15

1

4

High-throughput

0.445

High

529153

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

710829

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

710852

MOT9
Monocarboxylate transporter 9

1

4

High-throughput

0.445

High

710898

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.445

High

710921

KLDC2
Kelch domain-containing protein 2

1

1

Small-scale

0.445

High

566920

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.437

High

710830

SEPT6
Septin-6

1

14

High-throughput

0.437

High

710845

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.437

High

710859

PHAR4
Phosphatase and actin regulator 4

1

11

High-throughput

0.437

High

710890

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

710893

GORS2
Golgi reassembly-stacking protein 2

1

7

High-throughput

0.437

High

710906

USE1
Vesicle transport protein USE1

1

2

High-throughput

0.437

High

710908

SEP10
Septin-10

1

13

High-throughput

0.437

High

710911

SEPT3
Neuronal-specific septin-3

1

14

High-throughput

0.437

High

710912

SEPT9
Septin-9

1

14

High-throughput

0.437

High

710925

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

710903

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025