HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.60 0.657

The method score is based on:

Property Details
Experiments 30024968, 39499777, 32900848
Identification Methods affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001618 - virus receptor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0009925 - basal plasma membrane
and 4 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 236
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Service provided by Combinatics, Japan

Last updated: 11Aug2025