HitPredict

Interactor 1: CXL10 (P02778)
C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Gene: CXCL10

Interactor 2: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	18986693, 9794404, 17167270, 16253303
Identification Methods	electrophoretic mobility supershift assay, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 325
+	Hs
		150307 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		IRF1_HUMAN (1-325): 2.66e-166: 467: 100.00
+	Hs
		486172 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		IRF1_HUMAN (1-325): 2.66e-166: 467: 100.00
+	Mm
		576101 CXCL9_MOUSE (1-90): 3.44e-27: 97.8: 35.56		IRF8_MOUSE (7-270): 2.81e-94: 287: 28.03
+	Hs
		364099 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55
+	Hs
		150309 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55
+	Mm
		621185 CXL11_MOUSE (1-96): 7.43e-24: 88.6: 31.25		IRF2_MOUSE (1-259): 7.1e-83: 256: 45.22
+	Hs
		364114 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Hs
		486202 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Hs
		364111 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF9_HUMAN (7-267): 2.06e-56: 189: 26.02
+	Hs
		364117 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF7_HUMAN (4-252): 9.35e-41: 150: 21.09