HitPredict

Interactor 1: CXL10 (P02778)
C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Gene: CXCL10

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16253303
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042981 - regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0098586 - cellular response to virus GO:0140374 - antiviral innate immune response
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 427
+	Hs
		486202 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Mm
		576101 CXCL9_MOUSE (1-90): 3.44e-27: 97.8: 35.56		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Hs
		364111 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF9_HUMAN (7-388): 4.4e-113: 338: 23.87
+	Hs
		364117 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		364096 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		364099 CXL10_HUMAN (1-98): 4.33e-29: 101: 100.00		IRF2_HUMAN (1-116): 1.85e-48: 170: 33.90
+	Hs
		150307 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		150309 CXL11_HUMAN (1-94): 7.39e-27: 95.9: 30.85		IRF2_HUMAN (1-116): 1.85e-48: 170: 33.90
+	Mm
		621185 CXL11_MOUSE (1-96): 7.43e-24: 88.6: 31.25		IRF2_MOUSE (1-143): 5.2e-49: 171: 30.35
+	Hs
		486172 IL8_HUMAN (14-92): 7.33e-23: 86.3: 23.17		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23