Protein: K1C27
Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)

Gene: K1C27, KRT27
Organism: Homo sapiens
Interactions: 200
UniProt ID: Q7Z3Y8

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005882 - intermediate filament
GO:0030855 - epithelial cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091017

BFSP1
Filensin

3

20

High-throughput

0.858

High

227241

KRT86
Keratin, type II cuticular Hb6

2

20

High-throughput

0.783

High

341798

K2C75
Keratin, type II cytoskeletal 75

2

20

High-throughput

0.783

High

385295

K2C6A
Keratin, type II cytoskeletal 6A

2

20

High-throughput

0.783

High

407312

K2C6B
Keratin, type II cytoskeletal 6B

2

20

High-throughput

0.783

High

407484

K2C1
Keratin, type II cytoskeletal 1

2

20

High-throughput

0.783

High

437240

K2C8
Keratin, type II cytoskeletal 8

2

20

High-throughput

0.783

High

551569

K2C3
Keratin, type II cytoskeletal 3

2

20

High-throughput

0.783

High

566412

K2C5
Keratin, type II cytoskeletal 5

2

20

High-throughput

0.783

High

570477

GFAP
Glial fibrillary acidic protein

2

20

High-throughput

0.783

High

777403

K1C20
Keratin, type I cytoskeletal 20

2

20

High-throughput

0.783

High

777508

K22E
Keratin, type II cytoskeletal 2 epidermal

2

20

High-throughput

0.783

High

833304

PERI
Peripherin

2

20

High-throughput

0.783

High

876486

K2C6C
Keratin, type II cytoskeletal 6C

2

20

High-throughput

0.783

High

1007490

KRT83
Keratin, type II cuticular Hb3

2

20

High-throughput

0.783

High

1007527

KRT85
Keratin, type II cuticular Hb5

2

20

High-throughput

0.783

High

1031000

K22O
Keratin, type II cytoskeletal 2 oral

2

20

High-throughput

0.783

High

1108840

BFSP2
Phakinin

2

20

High-throughput

0.783

High

1127815

KRT81
Keratin, type II cuticular Hb1

2

20

High-throughput

0.783

High

1135575

K2C72
Keratin, type II cytoskeletal 72

2

20

High-throughput

0.783

High

1187820

K2C71
Keratin, type II cytoskeletal 71

2

20

High-throughput

0.783

High

1220464

K2C79
Keratin, type II cytoskeletal 79

2

20

High-throughput

0.783

High

1273937

K2C74
Keratin, type II cytoskeletal 74

2

20

High-throughput

0.783

High

1277567

K2C1B
Keratin, type II cytoskeletal 1b

2

20

High-throughput

0.783

High

1277574

K2C78
Keratin, type II cytoskeletal 78

2

20

High-throughput

0.783

High

1277642

KRT82
Keratin, type II cuticular Hb2

2

20

High-throughput

0.783

High

1104914

XRCC4
DNA repair protein XRCC4

2

0

High-throughput

0.742

High

451194

NFL
Neurofilament light polypeptide

1

20

High-throughput

0.691

High

451404

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.691

High

1157226

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

1277639

SYNCI
Syncoilin

1

20

High-throughput

0.691

High

333358

SNAPN
SNARE-associated protein Snapin

3

8

High-throughput

0.665

High

353708

DRC4
Dynein regulatory complex subunit 4

3

4

High-throughput

0.665

High

821135

TXLNA
Alpha-taxilin

3

20

High-throughput

0.665

High

618149

K2C4
Keratin, type II cytoskeletal 4

1

20

High-throughput

0.665

High

1047440

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

1277569

HOOK3
Protein Hook homolog 3

3

20

High-throughput

0.607

High

1277604

SGF29
SAGA-associated factor 29

3

7

High-throughput

0.607

High

163987

NDC80
Kinetochore protein NDC80 homolog

2

20

High-throughput

0.606

High

169618

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

16

High-throughput

0.606

High

257135

CCD22
Coiled-coil domain-containing protein 22

2

13

High-throughput

0.606

High

846363

MATR3
Matrin-3

2

4

High-throughput

0.606

High

920636

ARFP1
Arfaptin-1

2

3

High-throughput

0.606

High

941004

HDAC4
Histone deacetylase 4

2

17

High-throughput

0.606

High

968972

PRS8
26S proteasome regulatory subunit 8

2

4

High-throughput

0.606

High

1098570

GPS2
G protein pathway suppressor 2

2

2

High-throughput

0.606

High

1139176

JOS1
Josephin-1

2

2

High-throughput

0.606

High

1140180

ARHG6
Rho guanine nucleotide exchange factor 6

2

1

High-throughput

0.606

High

1213386

CFA58
Cilia- and flagella-associated protein 58

2

11

High-throughput

0.606

High

1239704

PPR18
Phostensin

2

8

High-throughput

0.606

High

1277573

CC146
Coiled-coil domain-containing protein 146

2

11

High-throughput

0.606

High

1277587

CCHCR
Coiled-coil alpha-helical rod protein 1

2

17

High-throughput

0.606

High

1277592

GOGA1
Golgin subfamily A member 1

2

4

High-throughput

0.606

High

1277608

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.606

High

1277612

MTMR9
Myotubularin-related protein 9

2

1

High-throughput

0.606

High

1277616

F110A
Protein FAM110A

2

2

High-throughput

0.606

High

1277634

PININ
Pinin

2

1

High-throughput

0.606

High

1277641

EXOS5
Exosome complex component RRP46

2

5

High-throughput

0.606

High

1277644

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

1277647

RCOR3
REST corepressor 3

2

6

High-throughput

0.606

High

1277653

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

1277655

SUFU
Suppressor of fused homolog

2

1

High-throughput

0.606

High

63221

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.580

High

303247

S22A5
Organic cation/carnitine transporter 2

2

0

High-throughput

0.580

High

568568

TNNT1
Troponin T, slow skeletal muscle

2

0

High-throughput

0.580

High

1277570

RASL3
RAS protein activator like-3

2

0

High-throughput

0.580

High

1277621

DUS26
Dual specificity protein phosphatase 26

2

0

High-throughput

0.580

High

1277658

GSTK1
Glutathione S-transferase kappa 1

2

0

High-throughput

0.580

High

1277661

VATD
V-type proton ATPase subunit D

2

0

High-throughput

0.580

High

1195724

AARD
Alanine- and arginine-rich domain-containing protein

2

1

High-throughput

0.561

High

51363

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

2

9

High-throughput

0.553

High

63302

ODAD3
Outer dynein arm-docking complex subunit 3

2

7

High-throughput

0.553

High

191968

TEX28
Testis-specific protein TEX28

2

1

High-throughput

0.553

High

217131

MS18B
Protein Mis18-beta

2

8

High-throughput

0.553

High

262400

DTNB
Dystrobrevin beta

2

10

High-throughput

0.553

High

288446

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

15

High-throughput

0.553

High

298014

SPF27
Pre-mRNA-splicing factor SPF27

2

5

High-throughput

0.553

High

352776

F107A
Actin-associated protein FAM107A

2

2

High-throughput

0.553

High

364154

MOS
Proto-oncogene serine/threonine-protein kinase mos

2

4

High-throughput

0.553

High

528468

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

2

High-throughput

0.553

High

600505

ZNF3
Zinc finger protein 3

2

3

High-throughput

0.553

High

604837

HXB9
Homeobox protein Hox-B9

2

12

High-throughput

0.553

High

666859

CCNC
Cyclin-C

2

7

High-throughput

0.553

High

902982

ZNF80
Zinc finger protein 80

2

2

High-throughput

0.553

High

907155

SUOX
Sulfite oxidase, mitochondrial

2

2

High-throughput

0.553

High

1055235

MTG8
Protein CBFA2T1

2

1

High-throughput

0.553

High

1135978

RTP5
Receptor-transporting protein 5

2

2

High-throughput

0.553

High

1150201

TEAD4
Transcriptional enhancer factor TEF-3

2

1

High-throughput

0.553

High

1180785

KLH38
Kelch-like protein 38

2

3

High-throughput

0.553

High

1212995

SKT
Sickle tail protein homolog

2

2

High-throughput

0.553

High

1220008

TTC23
Tetratricopeptide repeat protein 23

2

11

High-throughput

0.553

High

1224986

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

7

High-throughput

0.553

High

1228870

ZFY26
Zinc finger FYVE domain-containing protein 26

2

20

High-throughput

0.553

High

1245381

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

1

High-throughput

0.553

High

1249921

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

2

2

High-throughput

0.553

High

1271944

TEDC2
Tubulin epsilon and delta complex protein 2

2

10

High-throughput

0.553

High

1276128

NUP54
Nucleoporin p54

2

1

High-throughput

0.553

High

1277571

Q8IVT4
Hypothetical MGC50722

2

3

High-throughput

0.553

High

1277572

LMTD2
Lamin tail domain-containing protein 2

2

1

High-throughput

0.553

High

1277575

TXLNB
Beta-taxilin

2

20

High-throughput

0.553

High

1277576

USBP1
Harmonin-binding protein USHBP1

2

19

High-throughput

0.553

High

1277577

CC185
Coiled-coil domain-containing protein 185

2

8

High-throughput

0.553

High

1277578

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

11

High-throughput

0.553

High

1277579

MORN4
MORN repeat-containing protein 4

2

3

High-throughput

0.553

High

1277583

MB3L2
Methyl-CpG-binding domain protein 3-like 2

2

2

High-throughput

0.553

High

1277584

CA216
UPF0500 protein C1orf216

2

8

High-throughput

0.553

High

1277585

G45IP
Large ribosomal subunit protein mL64

2

1

High-throughput

0.553

High

1277586

SMRC2
SWI/SNF complex subunit SMARCC2

2

20

High-throughput

0.553

High

1277593

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

7

High-throughput

0.553

High

1277596

FAKD4
FAST kinase domain-containing protein 4

2

2

High-throughput

0.553

High

1277601

ZN669
Zinc finger protein 669

2

7

High-throughput

0.553

High

1277607

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

4

High-throughput

0.553

High

1277610

CC138
Coiled-coil domain-containing protein 138

2

1

High-throughput

0.553

High

1277614

THIOM
Thioredoxin, mitochondrial

2

2

High-throughput

0.553

High

1277619

THAP7
THAP domain-containing protein 7

2

2

High-throughput

0.553

High

1277623

NUP58
Nucleoporin p58/p45

2

1

High-throughput

0.553

High

1277624

SCNM1
Sodium channel modifier 1

2

3

High-throughput

0.553

High

1277625

BEX2
Protein BEX2

2

6

High-throughput

0.553

High

1277626

SEM4C
Semaphorin-4C

2

2

High-throughput

0.553

High

1277627

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

2

High-throughput

0.553

High

1277628

HPLN2
Hyaluronan and proteoglycan link protein 2

2

4

High-throughput

0.553

High

1277632

CCD68
Coiled-coil domain-containing protein 68

2

18

High-throughput

0.553

High

1277633

RNF39
RING finger protein 39

2

16

High-throughput

0.553

High

1277646

ZN581
Zinc finger protein 581

2

4

High-throughput

0.553

High

1277650

DPOLL
DNA polymerase lambda

2

2

High-throughput

0.553

High

1277654

ZN580
Zinc finger protein 580

2

3

High-throughput

0.553

High

1277657

T3JAM
TRAF3-interacting JNK-activating modulator

2

9

High-throughput

0.553

High

1277659

WASC3
WASH complex subunit 3

2

3

High-throughput

0.553

High

1277660

PCDBE
Protocadherin beta-14

2

1

High-throughput

0.553

High

64542

CC88B
Coiled-coil domain-containing protein 88B

1

11

High-throughput

0.536

High

322417

HAUS5
HAUS augmin-like complex subunit 5

1

1

High-throughput

0.536

High

945812

EPIPL
Epiplakin

1

20

High-throughput

0.536

High

1063134

GOGA3
Golgin subfamily A member 3

1

10

High-throughput

0.536

High

1112892

CUL2
Cullin-2

1

20

High-throughput

0.536

High

1143065

KPCD1
Serine/threonine-protein kinase D1

1

4

High-throughput

0.536

High

1144839

RABE1
Rab GTPase-binding effector protein 1

1

4

High-throughput

0.536

High

1226961

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.536

High

1246473

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

1

High-throughput

0.536

High

1277582

TNIP2
TNFAIP3-interacting protein 2

1

7

High-throughput

0.536

High

1277590

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

16

High-throughput

0.536

High

1277591

TSC1
Hamartin

1

20

High-throughput

0.536

High

1277597

EXOC4
Exocyst complex component 4

1

4

High-throughput

0.536

High

1277602

HAUS1
HAUS augmin-like complex subunit 1

1

3

High-throughput

0.536

High

1277603

SPDLY
Protein Spindly

1

8

High-throughput

0.536

High

1277605

DTBP1
Dysbindin

1

1

High-throughput

0.536

High

1277613

SPAG5
Sperm-associated antigen 5

1

15

High-throughput

0.536

High

1277622

CP250
Centrosome-associated protein CEP250

1

10

High-throughput

0.536

High

1277630

ATG5
Autophagy protein 5

1

5

High-throughput

0.536

High

1277631

GAN
Gigaxonin

1

11

High-throughput

0.536

High

1277637

HAUS4
HAUS augmin-like complex subunit 4

1

1

High-throughput

0.536

High

1277643

TXLNG
Gamma-taxilin

1

20

High-throughput

0.536

High

1277651

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

5

High-throughput

0.536

High

369358

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.513

High

933261

AIF1
Allograft inflammatory factor 1

1

0

High-throughput

0.513

High

1008476

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

High-throughput

0.513

High

1126855

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

0

High-throughput

0.513

High

1228537

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.513

High

1277617

KLDC3
Kelch domain-containing protein 3

1

0

High-throughput

0.513

High

1277635

CENPH
Centromere protein H

1

0

High-throughput

0.513

High

1277656

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.513

High

1198443

CEP55
Centrosomal protein of 55 kDa

1

2

High-throughput

0.489

High

1248139

SAS6
Spindle assembly abnormal protein 6 homolog

1

20

High-throughput

0.489

High

1277062

CC186
Coiled-coil domain-containing protein 186

1

10

High-throughput

0.489

High

1277581

NAV1
Neuron navigator 1

1

3

High-throughput

0.489

High

1277600

PF21A
PHD finger protein 21A

1

20

High-throughput

0.489

High

1277618

KXDL1
KxDL motif-containing protein 1

1

1

High-throughput

0.489

High

1277648

CING
Cingulin

1

4

High-throughput

0.489

High

1197001

AMOT
Angiomotin

1

20

High-throughput

0.481

High

1277611

FMNL2
Formin-like protein 2

1

1

High-throughput

0.481

High

1194184

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

1277640

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

14

High-throughput

0.479

High

59925

A2BDD9
AMOT protein

1

20

High-throughput

0.470

High

1081298

Q0VAL7
C21orf58 protein

1

3

High-throughput

0.470

High

1252735

Q6ZN96
cDNA FLJ16308 fis, clone PUAEN2006335

1

1

High-throughput

0.470

High

1277598

Q96AL5
PBX3 protein

1

3

High-throughput

0.470

High

1277595

RAB24
Ras-related protein Rab-24

1

6

High-throughput

0.445

High

1277636

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

823956

PBX3
Pre-B-cell leukemia transcription factor 3

1

3

High-throughput

0.439

High

946369

CU058
Uncharacterized protein C21orf58

1

3

High-throughput

0.439

High

324959

HEXI1
Protein HEXIM1

1

20

High-throughput

0.437

High

1271704

MEPCE
7SK snRNA methylphosphate capping enzyme

1

15

High-throughput

0.437

High

1277629

RNF38
E3 ubiquitin-protein ligase RNF38

1

10

Small-scale

0.437

High

65427

SDHF1
Succinate dehydrogenase assembly factor 1, mitochondrial

2

0

High-throughput

0.316

High

1250578

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.316

High

1277568

EX3L1
Exocyst complex component 3-like protein

2

0

High-throughput

0.316

High

1277580

ICA1L
Islet cell autoantigen 1-like protein

2

0

High-throughput

0.316

High

1277588

LKAM1
Protein LKAAEAR1

2

0

High-throughput

0.316

High

1277606

CEP95
Centrosomal protein of 95 kDa

2

0

High-throughput

0.316

High

1277609

RBM41
RNA-binding protein 41

2

0

High-throughput

0.316

High

1277615

SSX3
Protein SSX3

2

0

High-throughput

0.316

High

1277620

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

2

0

High-throughput

0.316

High

1277638

CS044
Uncharacterized protein C19orf44

2

0

High-throughput

0.316

High

1277649

GBG13

2

0

High-throughput

0.316

High

1277652

TSKS
Testis-specific serine kinase substrate

2

0

High-throughput

0.316

High

280013

SPAG7
Sperm-associated antigen 7

1

0

High-throughput

0.279

Low

1214154

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

1277589

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.279

Low

1277594

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.279

Low

1277599

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.279

Low

1277645

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025