HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: SGT1 (Q08446)
Protein SGT1 (Suppressor of G2 allele of SKP1)
Gene: SGT1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	15456868, 15340069, 15766533, 16945921, 31399574, 18818696, 18833289
Identification Methods	affinity chromatography technology, pull down, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 395
+	Hs
		438644 HS90B_HUMAN (5-709): 0: 1026: 62.13		SGT1_HUMAN (5-395): 1.67e-134: 391: 22.86
+	Hs
		432387 HS90A_HUMAN (4-709): 0: 1015: 60.83		SGT1_HUMAN (5-395): 1.67e-134: 391: 22.86
+	At
		646596 HS901_ARATH (3-709): 0: 1001: 64.03		SGT1A_ARATH (5-395): 6.45e-115: 340: 24.12
+	At
		646597 HS901_ARATH (3-709): 0: 1001: 64.03		SGT1B_ARATH (5-395): 2.34e-114: 339: 21.81
+	Mm
		513706 HS90B_MOUSE (5-709): 0: 1029: 61.68		ITBP2_MOUSE (113-281): 6.04e-47: 165: 15.21
+	Hs
		438609 HS90B_HUMAN (5-709): 0: 1026: 62.13		ITBP2_HUMAN (113-281): 4.01e-47: 165: 15.21
+	Hs
		432350 HS90A_HUMAN (4-709): 0: 1015: 60.83		ITBP2_HUMAN (113-281): 4.01e-47: 165: 15.21
+	Mm
		432458 HS90A_MOUSE (4-709): 0: 1012: 60.72		ITBP2_MOUSE (113-281): 6.04e-47: 165: 15.21
+	Mm
		513702 HS90B_MOUSE (5-709): 0: 1029: 61.68		CHRD1_MOUSE (113-291): 5.2e-38: 141: 16.85
+	Hs
		438592 HS90B_HUMAN (5-709): 0: 1026: 62.13		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Mm
		432455 HS90A_MOUSE (4-709): 0: 1012: 60.72		CHRD1_MOUSE (113-291): 5.2e-38: 141: 16.85
+	Hs
		111942 K9JA46_HUMAN (4-709): 0: 1015: 60.83		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Hs
		432333 HS90A_HUMAN (4-709): 0: 1015: 60.83		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Mm
		513680 HS90B_MOUSE (5-709): 0: 1029: 61.68		PPP5_MOUSE (5-185): 3.56e-18: 88.1: 18.68
+	Hs
		438021 HS90B_HUMAN (5-709): 0: 1026: 62.13		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Hs
		213454 HS90B_HUMAN (5-709): 0: 1026: 62.13		SGTA_HUMAN (5-152): 1.02e-14: 76.2: 18.79
+	Hs
		111935 K9JA46_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Hs
		431681 HS90A_HUMAN (4-709): 0: 1015: 60.83		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Mm
		432427 HS90A_MOUSE (4-709): 0: 1012: 60.72		PPP5_MOUSE (5-185): 3.56e-18: 88.1: 18.68
+	Hs
		213451 HS90A_HUMAN (4-709): 0: 1015: 60.83		SGTA_HUMAN (5-152): 1.02e-14: 76.2: 18.79