Protein: ATG12
Ubiquitin-like protein ATG12 (Autophagy-related protein 12)

Gene: ATG12
Organism: Saccharomyces cerevisiae S288C
Interactions: 153
UniProt ID: P38316

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000421 - autophagosome membrane
GO:0000422 - autophagy of mitochondrion
GO:0005829 - cytosol
GO:0008047 - enzyme activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798012

ATG5
Autophagy protein 5

13

3

Small-scale

0.985

High

797948

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

7

3

Small-scale

0.750

High

797989

ATG16
Autophagy protein 16

7

0

Small-scale

0.717

High

797961

ATG3
Autophagy-related protein 3

5

4

Small-scale

0.711

High

798001

ATG10
Ubiquitin-like-conjugating enzyme ATG10

4

0

Small-scale

0.656

High

797997

ATG17
Autophagy-related protein 17

3

0

Small-scale

0.651

High

798013

ATG31
Autophagy-related protein 31

3

0

Small-scale

0.603

High

763528

ATG19
Autophagy-related protein 19

2

1

Small-scale

0.595

High

795312

ATG8
Autophagy-related protein 8

2

3

Small-scale

0.595

High

797940

ATG12
Ubiquitin-like protein ATG12

1

0

Small-scale

0.586

High

798017

ATG11
Autophagy-related protein 11

2

0

Small-scale

0.585

High

415107

ADT1
ADP,ATP carrier protein 1

1

2

High-throughput

0.536

High

616415

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.536

High

736089

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

737712

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.536

High

797970

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

797971

ARC1
tRNA-aminoacylation cofactor ARC1

1

1

High-throughput

0.536

High

797975

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

Small-scale

0.529

High

452504

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.513

High

464323

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

797942

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.513

High

797949

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.513

High

797954

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.513

High

797964

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.513

High

797968

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.513

High

798014

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

797969

ATG18
Autophagy-related protein 18

1

1

Small-scale

0.501

High

797974

ATG1
Serine/threonine-protein kinase ATG1

1

1

Small-scale

0.501

High

367015

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.500

High

452896

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.500

High

453567

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.500

High

531313

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

621360

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.500

High

399364

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.489

High

613503

ADT3
ADP,ATP carrier protein 3

1

2

High-throughput

0.489

High

635957

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

721894

XPO1
Exportin-1

1

2

High-throughput

0.489

High

750928

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

High-throughput

0.489

High

797944

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.489

High

797995

RPN7
26S proteasome regulatory subunit RPN7

1

1

High-throughput

0.489

High

798007

RPN5
26S proteasome regulatory subunit RPN5

1

1

High-throughput

0.489

High

367381

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.479

High

394504

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.479

High

405082

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.479

High

408319

GAL1
Galactokinase

1

0

High-throughput

0.479

High

644765

CLH
Clathrin heavy chain

1

0

High-throughput

0.479

High

679618

CDC48
Cell division control protein 48

1

0

High-throughput

0.479

High

797979

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.479

High

798002

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

798008

ATG34
Autophagy-related protein 34

1

1

Small-scale

0.479

High

797169

ATG14
Autophagy-related protein 14

1

0

Small-scale

0.458

High

486154

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.457

High

486453

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.457

High

554915

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

590614

HSP26
Heat shock protein 26

1

1

High-throughput

0.457

High

592212

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.457

High

613567

ADT2
ADP,ATP carrier protein 2

1

2

High-throughput

0.457

High

619354

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

797984

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.457

High

523775

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526546

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

438200

CDC37
Hsp90 co-chaperone Cdc37

1

1

Small-scale

0.439

High

470620

AAP
Arginine attenuator peptide

1

0

High-throughput

0.438

High

503008

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.438

High

780547

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.438

High

797260

YBY7
UPF0303 protein YBR137W

1

0

High-throughput

0.438

High

797973

VPS4
Vacuolar protein sorting-associated protein 4

1

0

High-throughput

0.438

High

797982

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.438

High

798004

FDH1
Formate dehydrogenase 1

1

0

High-throughput

0.438

High

544677

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

745125

YME1
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

1

2

High-throughput

0.417

High

510438

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

797955

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

798010

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

627758

TYR1
Prephenate dehydrogenase [NADP(+)]

2

0

High-throughput

0.316

High

632557

DBP3
ATP-dependent RNA helicase DBP3

2

0

High-throughput

0.295

High

797998

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.295

High

366796

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.279

Low

471398

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.279

Low

479979

PRTB
Cerevisin

1

0

High-throughput

0.279

Low

518276

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.279

Low

575441

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

598854

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.279

Low

744496

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.279

Low

750830

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.279

Low

797943

PPX1
Polyphosphatase

1

0

High-throughput

0.279

Low

797945

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.279

Low

797947

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.279

Low

797951

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.279

Low

797956

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.279

Low

797960

YNU8
Uncharacterized protein YNL208W

1

0

High-throughput

0.279

Low

797965

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.279

Low

797977

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.279

Low

797980

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.279

Low

798011

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.279

Low

798016

TCB1
Tricalbin-1

1

0

High-throughput

0.279

Low

797953

PRM9
Pheromone-regulated membrane protein 9

1

0

High-throughput

0.265

Low

386690

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

397495

REP1
Partitioning protein REP1

1

0

High-throughput

0.261

Low

470516

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.261

Low

585552

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

594937

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.261

Low

661620

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

746270

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low

797957

IMB4
Importin subunit beta-4

1

0

High-throughput

0.261

Low

797962

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

797966

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

797981

ACT
Actin

1

0

High-throughput

0.261

Low

798015

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.261

Low

150216

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.238

Low

423586

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.238

Low

533476

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.238

Low

571276

PMS1
DNA mismatch repair protein PMS1

1

0

High-throughput

0.238

Low

632162

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.238

Low

654155

MAK32
Protein MAK32

1

0

High-throughput

0.238

Low

703810

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.238

Low

735259

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.238

Low

743605

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.238

Low

744041

ANP1
Mannan polymerase II complex ANP1 subunit

1

0

High-throughput

0.238

Low

744528

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.238

Low

748126

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.238

Low

761108

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.238

Low

782663

SRL3
Protein SRL3

1

0

High-throughput

0.238

Low

797811

YB47
Uncharacterized protein YBR197C

1

0

High-throughput

0.238

Low

797941

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.238

Low

797946

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.238

Low

797950

STN1
Protein STN1

1

0

High-throughput

0.238

Low

797952

MET30
F-box protein MET30

1

0

High-throughput

0.238

Low

797958

DDI1
DNA damage-inducible protein 1

1

0

High-throughput

0.238

Low

797959

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.238

Low

797963

FLX1
Mitochondrial FAD carrier protein FLX1

1

0

High-throughput

0.238

Low

797967

ZNF1
Respiratory transcription factor ZNF1

1

0

High-throughput

0.238

Low

797972

DS1P1
Dihydrosphingosine 1-phosphate phosphatase LCB3

1

0

High-throughput

0.238

Low

797976

FHN1
Non-classical export protein 2 homolog 1

1

0

High-throughput

0.238

Low

797978

TEX1
Protein TEX1

1

0

High-throughput

0.238

Low

797983

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.238

Low

797985

IRC15
Increased recombination centers protein 15

1

0

High-throughput

0.238

Low

797986

GIP3
GLC7-interacting protein 3

1

0

High-throughput

0.238

Low

797987

RMT2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.238

Low

797988

TMA23
Protein TMA23

1

0

High-throughput

0.238

Low

797990

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.238

Low

797991

LIC4
Protein ATC1/LIC4

1

0

High-throughput

0.238

Low

797992

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.238

Low

797993

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.238

Low

797994

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.238

Low

797996

NHEJ1
Non-homologous end-joining protein 1

1

0

High-throughput

0.238

Low

797999

SNA4
Protein SNA4

1

0

High-throughput

0.238

Low

798000

YD129
Uncharacterized protein YDL129W

1

0

High-throughput

0.238

Low

798003

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.238

Low

798005

YO392
Putative uncharacterized protein YOR392W

1

0

High-throughput

0.238

Low

798006

YP142
Putative uncharacterized protein YPL142C

1

0

High-throughput

0.238

Low

798009

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025