Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 20348541, 10619402, 17991765, 23403292, 12198596, 33731348, 19117995, 20353944, 12554772, 21182205, 23576398, 23159625, 18474858, unassigned1953, 11265755, 11682626
Identification Methods pull down, affinity chromatography technology, two hybrid, fluorescent resonance energy transfer, x-ray crystallography, tandem affinity purification, cosedimentation through density gradient, transcriptional complementation assay
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 75 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 595
Hs

1 595
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Last updated: 15 Jul 2024