Protein: SYYC
Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)

Gene: SYYC, TYS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 89
UniProt ID: P36421

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0004831 - tyrosine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740254

SMI1
Cell wall assembly regulator SMI1

3

0

Small-scale

0.651

High

392573

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.571

High

435010

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.571

High

526438

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

783492

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

Small-scale

0.537

High

783496

SYC
Cysteine--tRNA ligase

1

2

High-throughput

0.515

High

783509

TSA2
Peroxiredoxin TSA2

1

1

High-throughput

0.515

High

783513

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

2

High-throughput

0.515

High

783511

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.513

High

735887

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.493

High

783470

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.493

High

416110

SYTC
Threonine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

416222

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

558678

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

560795

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.479

High

579219

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

581849

SYKC
Lysine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

657078

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

670585

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

679580

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

687580

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

706825

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

726943

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

739345

ZUO1
Zuotin

1

2

High-throughput

0.479

High

783471

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

783472

YHI0
Putative proline--tRNA ligase YHR020W

1

3

High-throughput

0.479

High

783473

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

783474

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.479

High

783476

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

783478

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

783482

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

783484

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

783485

ARC1
tRNA-aminoacylation cofactor ARC1

1

1

High-throughput

0.479

High

783487

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.479

High

783494

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.479

High

783501

MAP1
Methionine aminopeptidase 1

1

2

High-throughput

0.479

High

783512

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

783518

RKM4
Ribosomal lysine N-methyltransferase 4

1

1

High-throughput

0.479

High

441844

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

454159

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

671920

RBSK
Ribokinase

1

0

High-throughput

0.458

High

709704

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

713611

EF1G1
Elongation factor 1-gamma 1

1

0

High-throughput

0.458

High

736375

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

High-throughput

0.458

High

750631

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

783475

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

Small-scale

0.458

High

783480

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

783490

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

783491

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

783495

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

783497

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.458

High

783500

TMA20
Translation machinery-associated protein 20

1

0

High-throughput

0.458

High

783503

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

783504

ESP1
Separin

1

0

High-throughput

0.458

High

783506

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

783510

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

783516

TRMB
tRNA

1

0

High-throughput

0.458

High

523654

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

531692

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

544522

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

741386

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

747299

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.445

High

783468

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.445

High

783479

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

783488

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

619158

IF5A2
Eukaryotic translation initiation factor 5A-2

1

1

High-throughput

0.437

High

783469

RM16
Large ribosomal subunit protein uL16m

1

1

High-throughput

0.437

High

783477

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

783515

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

435899

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.426

High

684689

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

783486

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

783498

ELOA1
Elongin-A

1

0

High-throughput

0.426

High

757934

SKT5
Chitin synthase regulator SKT5

1

1

High-throughput

0.407

High

783483

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.407

High

783493

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.299

High

783502

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.282

High

783481

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.269

Low

783505

RT10
Small ribosomal subunit protein uS10m

1

0

High-throughput

0.269

Low

783508

RT08
Small ribosomal subunit protein uS8m

1

0

High-throughput

0.269

Low

783489

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

689387

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

746794

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

783499

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

783507

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

783514

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.249

Low

783517

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

783519

EFG1P
rRNA-processing protein EFG1

1

0

Small-scale

0.249

Low

655436

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025